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Targeting cell surface receptors for axon regeneration in the central nervous system

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Targeting cell surface receptors for axon regeneration in the central nervous system. / Cheah, Menghon; Andrews, Melissa R.

In: Neural regeneration research, Vol. 11, No. 12, 05.01.2017, p. 1884-1887.

Research output: Contribution to journalArticle

Harvard

Cheah, M & Andrews, MR 2017, 'Targeting cell surface receptors for axon regeneration in the central nervous system', Neural regeneration research, vol. 11, no. 12, pp. 1884-1887. https://doi.org/10.4103/1673-5374.197079

APA

Cheah, M., & Andrews, M. R. (2017). Targeting cell surface receptors for axon regeneration in the central nervous system. Neural regeneration research, 11(12), 1884-1887. https://doi.org/10.4103/1673-5374.197079

Vancouver

Cheah M, Andrews MR. Targeting cell surface receptors for axon regeneration in the central nervous system. Neural regeneration research. 2017 Jan 5;11(12):1884-1887. https://doi.org/10.4103/1673-5374.197079

Author

Cheah, Menghon ; Andrews, Melissa R. / Targeting cell surface receptors for axon regeneration in the central nervous system. In: Neural regeneration research. 2017 ; Vol. 11, No. 12. pp. 1884-1887.

Bibtex Download

@article{2f3d15f917d640d093e4c97036159c4c,
title = "Targeting cell surface receptors for axon regeneration in the central nervous system",
abstract = "Axon regeneration in the CNS is largely unsuccessful due to excess inhibitory extrinsic factors within lesion sites together with an intrinsic inability of neurons to regrow following injury. Recent work demonstrates that forced expression of certain neuronal transmembrane receptors can recapitulate neuronal growth resulting in successful growth within and through inhibitory lesion environments. More specifically, neuronal expression of integrin receptors such as alpha9beta1 integrin which binds the extracellular matrix glycoprotein tenascin-C, trk receptors such as trkB which binds the neurotrophic factor BDNF, and receptor PTPσ which binds chondroitin sulphate proteoglycans, have all been show to significantly enhance regeneration of injured axons. We discuss how reintroduction of these receptors in damaged neurons facilitates signalling from the internal environment of the cell with the external environment of the lesion milieu, effectively resulting in growth and repair following injury. In summary, we suggest an appropriate balance of intrinsic and extrinsic factors are required to obtain substantial axon regeneration.",
author = "Menghon Cheah and Andrews, {Melissa R}",
year = "2017",
month = jan,
day = "5",
doi = "10.4103/1673-5374.197079",
language = "English",
volume = "11",
pages = "1884--1887",
journal = "Neural regeneration research",
issn = "1673-5374",
publisher = "Editorial Board of Neural Regeneration Research",
number = "12",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Targeting cell surface receptors for axon regeneration in the central nervous system

AU - Cheah, Menghon

AU - Andrews, Melissa R

PY - 2017/1/5

Y1 - 2017/1/5

N2 - Axon regeneration in the CNS is largely unsuccessful due to excess inhibitory extrinsic factors within lesion sites together with an intrinsic inability of neurons to regrow following injury. Recent work demonstrates that forced expression of certain neuronal transmembrane receptors can recapitulate neuronal growth resulting in successful growth within and through inhibitory lesion environments. More specifically, neuronal expression of integrin receptors such as alpha9beta1 integrin which binds the extracellular matrix glycoprotein tenascin-C, trk receptors such as trkB which binds the neurotrophic factor BDNF, and receptor PTPσ which binds chondroitin sulphate proteoglycans, have all been show to significantly enhance regeneration of injured axons. We discuss how reintroduction of these receptors in damaged neurons facilitates signalling from the internal environment of the cell with the external environment of the lesion milieu, effectively resulting in growth and repair following injury. In summary, we suggest an appropriate balance of intrinsic and extrinsic factors are required to obtain substantial axon regeneration.

AB - Axon regeneration in the CNS is largely unsuccessful due to excess inhibitory extrinsic factors within lesion sites together with an intrinsic inability of neurons to regrow following injury. Recent work demonstrates that forced expression of certain neuronal transmembrane receptors can recapitulate neuronal growth resulting in successful growth within and through inhibitory lesion environments. More specifically, neuronal expression of integrin receptors such as alpha9beta1 integrin which binds the extracellular matrix glycoprotein tenascin-C, trk receptors such as trkB which binds the neurotrophic factor BDNF, and receptor PTPσ which binds chondroitin sulphate proteoglycans, have all been show to significantly enhance regeneration of injured axons. We discuss how reintroduction of these receptors in damaged neurons facilitates signalling from the internal environment of the cell with the external environment of the lesion milieu, effectively resulting in growth and repair following injury. In summary, we suggest an appropriate balance of intrinsic and extrinsic factors are required to obtain substantial axon regeneration.

U2 - 10.4103/1673-5374.197079

DO - 10.4103/1673-5374.197079

M3 - Article

C2 - 28197173

VL - 11

SP - 1884

EP - 1887

JO - Neural regeneration research

JF - Neural regeneration research

SN - 1673-5374

IS - 12

ER -

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