Taxane diterpenes 1. Control of relative and absolute stereochemistry in intramolecular pyrylium ylide-alkene cyclizations for the synthesis of taxol precursors

William E. Bauta, John Booth, Mary E. Bos, Mark DeLuca, Louis Diorazio, Timothy J. Donohoe, Christopher Frost, Nicholas Magnus, Philip Magnus*, José Mendoza, Philip Pye, James G. Tarrant, Stephen Thom, Feroze Ujjainwalla

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Intramolecular pyrylium ylide-alkene cyclizations provide control of the absolute stereochemistry at the crucial C-19 angular methyl group, and leads to bicyclo[5.4.03,8]undecenones that contain the structral elements of the B/C rings of the taxanes.

Original languageEnglish
Pages (from-to)14081-14102
Number of pages22
JournalTETRAHEDRON
Volume52
Issue number45
DOIs
Publication statusPublished - 4 Nov 1996

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