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Technical Pitfalls and Limitations of SPECT/CT

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)530-40
Number of pages11
JournalSeminars in Nuclear Medicine
Issue number6
PublishedNov 2015


  • YSNUC_50563_Oct15_

    YSNUC_50563_Oct15_.pdf, 4.12 MB, application/pdf

    Uploaded date:08 Jan 2016

    Version:Accepted author manuscript

King's Authors


The synergy of functional and anatomic information in hybrid systems has undoubtedly enhanced the diagnostic potential of radionuclide imaging in recent years, contributing to the advancement of SPECT/CT in clinical practice. Since the introduction of commercial SPECT/CT in the late 1990s, the field has seen rapid expansion and development toward multidetector CT subsystems, establishing the role of SPECT/CT as a routine imaging tool. It is, however, important to discuss possible challenges and technical limitations of such systems and how these influence imaging outcomes. In particular, the issues of patient motion and spatial misalignment of the SPECT and CT modalities, data corrections such as those for photon attenuation, and the choice of CT acquisition protocols in relation to radiation exposure are discussed in the article.

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