Telocytes regulate macrophages in periodontal disease

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5 Citations (Scopus)

Abstract

Telocytes (TCs) or interstitial cells are characterised in vivo by their long projections that contact other cell types. Although telocytes can be found in many different tissues including the heart , lung and intestine , their tissue-specific roles are poorly understood. Here we identify a specific cell signalling role for telocytes in the periodontium whereby telocytes regulate macrophage activity. We performed scRNA-seq and lineage tracing to identify telocytes and macrophages in mouse periodontium in homeostasis and periodontitis and carried out HGF signalling inhibition experiments using Tivantinib. We show that telocytes are quiescent in homeostasis, however, they proliferate and serve as a major source of HGF in periodontitis. Macrophages receive telocyte-derived HGF signals and shift from an M1 to a M1/M2 state. Our results reveal the source of HGF signals in periodontal tissue and provide new insights into the function of telocytes in regulating macrophage behaviour in periodontitis through HGF/Met cell signalling, that may provide a novel approach in periodontitis treatment. [Abstract copyright: © 2022, Zhao et al.]
Original languageEnglish
JournaleLife
Volume11
Early online date4 Oct 2022
DOIs
Publication statusE-pub ahead of print - 4 Oct 2022

Keywords

  • mouse
  • cell biology

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