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Temporal changes within mechanical dyssynchrony and rotational mechanics in Takotsubo syndrome: A cardiovascular magnetic resonance imaging study

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Temporal changes within mechanical dyssynchrony and rotational mechanics in Takotsubo syndrome: A cardiovascular magnetic resonance imaging study. / Backhaus, Sören J.; Stiermaier, Thomas; Lange, Torben; Chiribiri, Amedeo; Lamata, Pablo; Uhlig, Johannes; Kowallick, Johannes; Raaz, Uwe; Villa, Adriana; Lotz, Joachim; Hasenfuß, Gerd; Thiele, Holger; Eitel, Ingo; Schuster, Andreas.

In: International Journal of Cardiology, 22.04.2018.

Research output: Contribution to journalArticle

Harvard

Backhaus, SJ, Stiermaier, T, Lange, T, Chiribiri, A, Lamata, P, Uhlig, J, Kowallick, J, Raaz, U, Villa, A, Lotz, J, Hasenfuß, G, Thiele, H, Eitel, I & Schuster, A 2018, 'Temporal changes within mechanical dyssynchrony and rotational mechanics in Takotsubo syndrome: A cardiovascular magnetic resonance imaging study' International Journal of Cardiology. DOI: 10.1016/j.ijcard.2018.04.088

APA

Backhaus, S. J., Stiermaier, T., Lange, T., Chiribiri, A., Lamata, P., Uhlig, J., ... Schuster, A. (2018). Temporal changes within mechanical dyssynchrony and rotational mechanics in Takotsubo syndrome: A cardiovascular magnetic resonance imaging study. DOI: 10.1016/j.ijcard.2018.04.088

Vancouver

Backhaus SJ, Stiermaier T, Lange T, Chiribiri A, Lamata P, Uhlig J et al. Temporal changes within mechanical dyssynchrony and rotational mechanics in Takotsubo syndrome: A cardiovascular magnetic resonance imaging study. International Journal of Cardiology. 2018 Apr 22. Available from, DOI: 10.1016/j.ijcard.2018.04.088

Author

Backhaus, Sören J. ; Stiermaier, Thomas ; Lange, Torben ; Chiribiri, Amedeo ; Lamata, Pablo ; Uhlig, Johannes ; Kowallick, Johannes ; Raaz, Uwe ; Villa, Adriana ; Lotz, Joachim ; Hasenfuß, Gerd ; Thiele, Holger ; Eitel, Ingo ; Schuster, Andreas. / Temporal changes within mechanical dyssynchrony and rotational mechanics in Takotsubo syndrome: A cardiovascular magnetic resonance imaging study. In: International Journal of Cardiology. 2018

Bibtex Download

@article{ffbbabf0567646d08f61c44626cb4785,
title = "Temporal changes within mechanical dyssynchrony and rotational mechanics in Takotsubo syndrome: A cardiovascular magnetic resonance imaging study",
abstract = "Background The pathophysiological significance of dyssynchrony and rotation in Takotsubo syndrome (TTS) is unknown. We aimed to define the influence of cardiovascular magnetic resonance feature tracking (CMR-FT) dyssynchrony and rotational mechanics in acute and during clinical course of TTS. Methods This multicenter study included 152 TTS patients undergoing CMR (mean 3 days after symptom onset). Apical, midventricular and basal short axis views were analysed in a core-laboratory. Systolic torsion, diastolic recoil and dyssynchrony expressed as circumferential and radial uniformity ratio estimates (CURE and RURE: 0 to 1; 1 = perfect synchrony) were compared to a matched control group (n = 21). Follow-up CMR (n = 20 patients; mean 62 days, SD 7.2) and general follow-up (n = 136; mean 3.3 years, SD 2.4) were performed. Results CURE was initially reduced compared to controls (p = 0.001) and recovered at follow-up (p < 0.001) as opposed to RURE (p = 0.116 and p = 0.179). CURE and RURE discriminated between ballooning patterns (p = 0.001 and p = 0.045). Recoil was generally impaired during the acute phase (p = 0.015), torsion only in highly dyssynchronous patients (p = 0.024). Diabetes (p = 0.007), physical triggers (p = 0.013) and malignancies (p = 0.001) predicted mortality. The latter showed a distinct association with impaired torsion (p = 0.042) and dyssynchrony (p = 0.047). Physical triggers and malignancies were related to biventricular impairment (p = 0.004 and p = 0.026), showing higher dyssynchrony (p < 0.01), greater reduction of left ventricular function (p < 0.001) and a strong trend towards increased mortality (p = 0.074). Conclusion Transient circumferential dyssynchrony and impaired rotational mechanics are distinct features of TTS with different severities according to the pattern of ballooning. Patients with malignancies and precipitating physical triggers frequently show biventricular affection, greater dyssynchrony and high mortality risk.",
author = "Backhaus, {S{\"o}ren J.} and Thomas Stiermaier and Torben Lange and Amedeo Chiribiri and Pablo Lamata and Johannes Uhlig and Johannes Kowallick and Uwe Raaz and Adriana Villa and Joachim Lotz and Gerd Hasenfu{\ss} and Holger Thiele and Ingo Eitel and Andreas Schuster",
year = "2018",
month = "4",
day = "22",
doi = "10.1016/j.ijcard.2018.04.088",
language = "English",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Temporal changes within mechanical dyssynchrony and rotational mechanics in Takotsubo syndrome: A cardiovascular magnetic resonance imaging study

AU - Backhaus,Sören J.

AU - Stiermaier,Thomas

AU - Lange,Torben

AU - Chiribiri,Amedeo

AU - Lamata,Pablo

AU - Uhlig,Johannes

AU - Kowallick,Johannes

AU - Raaz,Uwe

AU - Villa,Adriana

AU - Lotz,Joachim

AU - Hasenfuß,Gerd

AU - Thiele,Holger

AU - Eitel,Ingo

AU - Schuster,Andreas

PY - 2018/4/22

Y1 - 2018/4/22

N2 - Background The pathophysiological significance of dyssynchrony and rotation in Takotsubo syndrome (TTS) is unknown. We aimed to define the influence of cardiovascular magnetic resonance feature tracking (CMR-FT) dyssynchrony and rotational mechanics in acute and during clinical course of TTS. Methods This multicenter study included 152 TTS patients undergoing CMR (mean 3 days after symptom onset). Apical, midventricular and basal short axis views were analysed in a core-laboratory. Systolic torsion, diastolic recoil and dyssynchrony expressed as circumferential and radial uniformity ratio estimates (CURE and RURE: 0 to 1; 1 = perfect synchrony) were compared to a matched control group (n = 21). Follow-up CMR (n = 20 patients; mean 62 days, SD 7.2) and general follow-up (n = 136; mean 3.3 years, SD 2.4) were performed. Results CURE was initially reduced compared to controls (p = 0.001) and recovered at follow-up (p < 0.001) as opposed to RURE (p = 0.116 and p = 0.179). CURE and RURE discriminated between ballooning patterns (p = 0.001 and p = 0.045). Recoil was generally impaired during the acute phase (p = 0.015), torsion only in highly dyssynchronous patients (p = 0.024). Diabetes (p = 0.007), physical triggers (p = 0.013) and malignancies (p = 0.001) predicted mortality. The latter showed a distinct association with impaired torsion (p = 0.042) and dyssynchrony (p = 0.047). Physical triggers and malignancies were related to biventricular impairment (p = 0.004 and p = 0.026), showing higher dyssynchrony (p < 0.01), greater reduction of left ventricular function (p < 0.001) and a strong trend towards increased mortality (p = 0.074). Conclusion Transient circumferential dyssynchrony and impaired rotational mechanics are distinct features of TTS with different severities according to the pattern of ballooning. Patients with malignancies and precipitating physical triggers frequently show biventricular affection, greater dyssynchrony and high mortality risk.

AB - Background The pathophysiological significance of dyssynchrony and rotation in Takotsubo syndrome (TTS) is unknown. We aimed to define the influence of cardiovascular magnetic resonance feature tracking (CMR-FT) dyssynchrony and rotational mechanics in acute and during clinical course of TTS. Methods This multicenter study included 152 TTS patients undergoing CMR (mean 3 days after symptom onset). Apical, midventricular and basal short axis views were analysed in a core-laboratory. Systolic torsion, diastolic recoil and dyssynchrony expressed as circumferential and radial uniformity ratio estimates (CURE and RURE: 0 to 1; 1 = perfect synchrony) were compared to a matched control group (n = 21). Follow-up CMR (n = 20 patients; mean 62 days, SD 7.2) and general follow-up (n = 136; mean 3.3 years, SD 2.4) were performed. Results CURE was initially reduced compared to controls (p = 0.001) and recovered at follow-up (p < 0.001) as opposed to RURE (p = 0.116 and p = 0.179). CURE and RURE discriminated between ballooning patterns (p = 0.001 and p = 0.045). Recoil was generally impaired during the acute phase (p = 0.015), torsion only in highly dyssynchronous patients (p = 0.024). Diabetes (p = 0.007), physical triggers (p = 0.013) and malignancies (p = 0.001) predicted mortality. The latter showed a distinct association with impaired torsion (p = 0.042) and dyssynchrony (p = 0.047). Physical triggers and malignancies were related to biventricular impairment (p = 0.004 and p = 0.026), showing higher dyssynchrony (p < 0.01), greater reduction of left ventricular function (p < 0.001) and a strong trend towards increased mortality (p = 0.074). Conclusion Transient circumferential dyssynchrony and impaired rotational mechanics are distinct features of TTS with different severities according to the pattern of ballooning. Patients with malignancies and precipitating physical triggers frequently show biventricular affection, greater dyssynchrony and high mortality risk.

U2 - 10.1016/j.ijcard.2018.04.088

DO - 10.1016/j.ijcard.2018.04.088

M3 - Article

JO - International Journal of Cardiology

T2 - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -

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