@article{4ba28b74b8bb4273b29950cf776d58a3,
title = "Temporal profile of intranasal oxytocin in the human autonomic nervous system at rest: An electrocardiography and pupillometry study",
abstract = "Background: Human social behavior is modulated by oxytocin (OT). Intranasal administration of OT (IN-OT) is a noninvasive route shown to elicit changes in the autonomic nervous system (ANS) activity; however, IN-OT{\textquoteright}s effect on the temporal profile of ANS activity at rest is yet to be described. Aims: We aimed to describe the temporal profile of IN-OT at six 10-min time windows from 15- to 100-min post-administration in 20 male participants at rest while continuously recording their pupillary in an eyes-open condition and cardiac activity in eyes-open and eyes-closed conditions. Methods: We used a double-blind, placebo-controlled, within-subjects design study where we extracted two proxies of parasympathetic nervous system (PNS) activity: high-frequency heart rate variability (HF-HRV) and pupillary unrest index (PUI); and a proxy of sympathetic nervous system activity: sample entropy of the pupillary unrest. Results: In the eyes-open condition, we found an effect of IN-OT on the proxies of PNS activity: decreased PUI in the three-time windows post-administration spanning 65–100 min, and as an exploratory finding, an increased HF-HRV in the 80–85 min time window. Conclusions: We suggest there is a role of OT in PNS regulation that may be consistent with OT{\textquoteright}s currently theorized role in the facilitation of alertness and approach behavior.",
keywords = "Electrocardiography, neuropeptide, pharmacodynamics, pupil unrest, resting state",
author = "Gon{\c c}alo Cosme and Patr{\'i}cia Arriaga and Rosa, {Pedro J.} and Mehta, {Mitul A.} and Diana Prata",
note = "Funding Information: We would like to thank the Direction of the Clinical Research Centre (Centro de Investiga{\c c}{\~a}o Cl{\'i}nica) of the Lisbon Medical Academic Center (Centro Acad{\'e}mico M{\'e}dico de Lisboa), represented by Prof. Lu{\'i}s Costa, for allowing us to conduct the experimental sessions in its facilities. We would also like to thank Marie Zelenina, M{\'o}nica Costa, and Katja Brodmann for their contribution to participants{\textquoteright} recruitment and data collection and all the participants who made this study possible. We thank Jasmine Ho for proofreading the final manuscript. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia PhD fellowship (SFRH/BD/148088/2019) to GC. By the European Commission Seventh Framework Programme Marie Curie Career Integration Grant (FP7-PEOPLE-2013-CIG-631952), the 2016 Bial Foundation Psychophysiology Grant grant—(Ref. 292/16), and FCT{\textquoteright}s (IF/00787/2014), (LISBOA-01-0145-FEDER-030907) and (UIDB/00645/2020) grants to DP. DP was also the recipient of the FCT (DSAIPA/DS/0065/2018) grant and the iMM Lisboa Director{\textquoteright}s Fund Breakthrough Idea Grant 2016 and is co-founder and shareholder of the neuroimaging research services company NeuroPsyAI, Ltd. Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia PhD fellowship (SFRH/BD/148088/2019) to GC. By the European Commission Seventh Framework Programme Marie Curie Career Integration Grant (FP7-PEOPLE-2013-CIG-631952), the 2016 Bial Foundation Psychophysiology Grant grant—(Ref. 292/16), and FCT{\textquoteright}s (IF/00787/2014), (LISBOA-01-0145-FEDER-030907) and (UIDB/00645/2020) grants to DP. DP was also the recipient of the FCT (DSAIPA/DS/0065/2018) grant and the iMM Lisboa Director{\textquoteright}s Fund Breakthrough Idea Grant 2016 and is co-founder and shareholder of the neuroimaging research services company NeuroPsyAI, Ltd. Publisher Copyright: {\textcopyright} The Author(s) 2023.",
year = "2023",
month = jun,
doi = "10.1177/02698811231158233",
language = "English",
volume = "37",
pages = "566--576",
journal = "Journal of Psychopharmacology",
issn = "0269-8811",
publisher = "Sage Publications",
number = "6",
}