Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study

Camice Revier; Ulrich Reininghaus; Rina Dutta; Paul Fearon; Robin Murray; Gillian Doody; Tim Croudace; Paola Dazzan; Margaret Heslin; Adanna Onyejiaka; Eugenia Kravariti; Julia Lappin; Ben Lomas; James B. Kirkbride; Kim Donoghue; Craig Morgan; Peter B. Jones

doi:10.1097/NMD.0000000000000295

Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study

Camice Revier, Ulrich Reininghaus, Rina Dutta, Paul Fearon, Robin Murray, Gillian Doody, Tim Croudace, Paola Dazzan, Margaret Heslin, Adanna Onyejiaka, Eugenia Kravariti, Julia Lappin, Ben Lomas, James B. Kirkbride, Kim Donoghue, Craig Morgan, Peter B. Jones

Research output: Contribution to journal › Article › peer-review

91 Citations (Scopus)

Abstract

It has long been held that schizophrenia and other psychotic disorders
have a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes fromtheÆSOP-10multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90%when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditions
were first described.

Original language	English
Pages (from-to)	379-386
Number of pages	8
Journal	The Journal of nervous and mental disease
Volume	203
Issue number	5
DOIs	https://doi.org/10.1097/NMD.0000000000000295
Publication status	Published - May 2015

Access to Document

10.1097/NMD.0000000000000295

http://journals.lww.com/jonmd/Abstract/publishahead/Ten_Year_Outcomes_of_First_Episode_Psychoses_in.99806.aspx

Cite this

Revier, C., Reininghaus, U., Dutta, R., Fearon, P., Murray, R., Doody, G., Croudace, T., Dazzan, P., Heslin, M., Onyejiaka, A., Kravariti, E., Lappin, J., Lomas, B., Kirkbride, J. B., Donoghue, K., Morgan, C., & Jones, P. B. (2015). Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study. The Journal of nervous and mental disease, 203(5), 379-386. https://doi.org/10.1097/NMD.0000000000000295

@article{121ef75a29904adfaf0ec3afec741ea9,

title = "Ten-Year Outcomes of First-Episode Psychoses in the MRC {\AE}SOP-10 Study",

abstract = "It has long been held that schizophrenia and other psychotic disordershave a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes fromthe{\AE}SOP-10multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90%when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditionswere first described.",

author = "Camice Revier and Ulrich Reininghaus and Rina Dutta and Paul Fearon and Robin Murray and Gillian Doody and Tim Croudace and Paola Dazzan and Margaret Heslin and Adanna Onyejiaka and Eugenia Kravariti and Julia Lappin and Ben Lomas and Kirkbride, {James B.} and Kim Donoghue and Craig Morgan and Jones, {Peter B.}",

year = "2015",

month = may,

doi = "10.1097/NMD.0000000000000295",

language = "English",

volume = "203",

pages = "379--386",

journal = "The Journal of nervous and mental disease",

issn = "1539-736X",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

number = "5",

}

Revier, C, Reininghaus, U , Dutta, R, Fearon, P, Murray, R, Doody, G, Croudace, T, Dazzan, P , Heslin, M , Onyejiaka, A , Kravariti, E , Lappin, J, Lomas, B, Kirkbride, JB, Donoghue, K , Morgan, C & Jones, PB 2015, 'Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study', The Journal of nervous and mental disease, vol. 203, no. 5, pp. 379-386. https://doi.org/10.1097/NMD.0000000000000295

TY - JOUR

T1 - Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study

AU - Revier, Camice

AU - Reininghaus, Ulrich

AU - Dutta, Rina

AU - Fearon, Paul

AU - Murray, Robin

AU - Doody, Gillian

AU - Croudace, Tim

AU - Dazzan, Paola

AU - Heslin, Margaret

AU - Onyejiaka, Adanna

AU - Kravariti, Eugenia

AU - Lappin, Julia

AU - Lomas, Ben

AU - Kirkbride, James B.

AU - Donoghue, Kim

AU - Morgan, Craig

AU - Jones, Peter B.

PY - 2015/5

Y1 - 2015/5

N2 - It has long been held that schizophrenia and other psychotic disordershave a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes fromtheÆSOP-10multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90%when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditionswere first described.

AB - It has long been held that schizophrenia and other psychotic disordershave a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes fromtheÆSOP-10multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90%when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditionswere first described.

U2 - 10.1097/NMD.0000000000000295

DO - 10.1097/NMD.0000000000000295

M3 - Article

SN - 1539-736X

VL - 203

SP - 379

EP - 386

JO - The Journal of nervous and mental disease

JF - The Journal of nervous and mental disease

IS - 5

ER -