Statement of problem: Long-term clinical data on the survival of pressed lithium disilicate glass-ceramic restorations and the effect that different technical and clinical variables have on survival are lacking. Purpose: The purpose of this clinical study was to examine the 10-year survival of pressed lithium disilicate glass-ceramic restorations and the relationship between clinical parameters on outcomes. Material and methods: Five hundred and fifty-six patients, ranging in age from 17 to 97 years, from a private clinical practice were enrolled. All participants required single-tooth replacement or repair in any area of the mouth, including single crowns, 3-unit fixed partial dentures, cantilevered anterior restorations, and foundation restorations. Together, the longevity of 1960 complete-coverage restorations was studied. Participants were offered the options of gold, conventional metal-ceramic, or lithium disilicate restoration. Participants who chose glass-ceramic restorations were included in the study. The overall survival of the glass-ceramic restorations was assessed by using clinical factors determined at recall, and the effect of various clinical parameters was evaluated by using Kaplan-Meier survival curves to account for attrition bias and other reasons for failure. The statistical significance of differences between parameters was determined using the log-rank test (α=.05). Results: A total of 556 patients electing lithium disilicate restorations were evaluated. The mean age of patients at the time of restoration placement was 62 years, with a range of 17 to 97 years. Men comprised 39.5% of the patients, and women, 60.5%. Many patients required more than one restoration. Seven failures (bulk fracture or large chip requiring replacement)were recorded for the 1960 complete-coverage lithium disilicate restorations, with the average time of failure being 4.2 years. The total time at risk computed for the units was 5113 years, providing an estimated failure risk of 0.14% per year. The 10-year estimated cumulative survival was 99.6% (95% confidence: 99.4-99.8).The estimated cumulative survival rate of 1410 monolithic and 550 bilayered e.max complete-coverage restorations was 96.5% and 100%, respectively, at 10.4 and 7.9 years (P<.05). Seven failures were recorded for the monolithic complete-coverage restoration units placed. The total time at risk for these monolithic units was 3380 years, providing an estimated risk of 0.2% per year. Failures were primarily in molar teeth (5 of 7)and occurred in both arches (3/2). No failures were recorded for the bilayered complete-coverage restorations. The total time at risk computed for the bilayered units was 1733 years, providing an estimated risk of 0% per year. Conclusions: Pressed lithium disilicate restorations in this study survived successfully over the 10.4-year period studied with an overall failure rate below 0.2% per year and were primarily confined to molar teeth. The risk of failure at any age was minimal for both men and women.