Test-retest reliability of time-varying patterns of brain activity across single band and multiband resting-state functional magnetic resonance imaging in healthy older adults

Marie Stephanie Cahart; Flavio Dell’Acqua; Vincent Giampietro; Joana Cabral; Maarten Timmers; Johannes Streffer; Steven Einstein; Fernando Zelaya; Steven C.R. Williams; Owen O’Daly

doi:10.3389/fnhum.2022.980280

Test-retest reliability of time-varying patterns of brain activity across single band and multiband resting-state functional magnetic resonance imaging in healthy older adults

Marie Stephanie Cahart^*, Flavio Dell’Acqua, Vincent Giampietro, Joana Cabral, Maarten Timmers, Johannes Streffer, Steven Einstein, Fernando Zelaya, Steven C.R. Williams, Owen O’Daly

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Leading Eigenvector Dynamics Analysis (LEiDA) is an analytic approach that characterizes brain activity recorded with functional Magnetic Resonance Imaging (fMRI) as a succession of discrete phase-locking patterns, or states, that consistently recur over time across all participants. LEiDA allows for the extraction of three state-related measures which have previously been key to gaining a better understanding of brain dynamics in both healthy and clinical populations: the probability of occurrence of a given state, its lifetime and the probability of switching from one state to another. The degree to which test-retest reliability of the LEiDA measures may be affected by increasing MRI multiband (MB) factors in comparison with single band sequences is yet to be established. In this study, 24 healthy older adults were scanned over three sessions, on weeks 0, 1, and 4. On each visit, they underwent a conventional single band resting-state fMRI (rs-fMRI) scan and three different MB rs-fMRI scans, with MB factors of 4, with and without in-plane acceleration, and 6 without in-plane acceleration. We found test-retest reliability scores to be significantly higher with MB factor 4 with and without in-plane acceleration for most cortical networks. These findings will inform the choice of acquisition parameters for future studies and clinical trials.

Original language	English
Article number	980280
Journal	Frontiers In Human Neuroscience
Volume	16
DOIs	https://doi.org/10.3389/fnhum.2022.980280
Publication status	Published - 10 Nov 2022

Keywords

brain dynamics
functional connectivity
multiband (MB)
phase synchronization
reliability
resting-state
single band

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10.3389/fnhum.2022.980280Licence: CC BY

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Cahart, M. S., Dell’Acqua, F., Giampietro, V., Cabral, J., Timmers, M., Streffer, J., Einstein, S., Zelaya, F., Williams, S. C. R., & O’Daly, O. (2022). Test-retest reliability of time-varying patterns of brain activity across single band and multiband resting-state functional magnetic resonance imaging in healthy older adults. Frontiers In Human Neuroscience, 16, Article 980280. https://doi.org/10.3389/fnhum.2022.980280

@article{2a8927c3dd7843d794e7129f88d63d26,

title = "Test-retest reliability of time-varying patterns of brain activity across single band and multiband resting-state functional magnetic resonance imaging in healthy older adults",

abstract = "Leading Eigenvector Dynamics Analysis (LEiDA) is an analytic approach that characterizes brain activity recorded with functional Magnetic Resonance Imaging (fMRI) as a succession of discrete phase-locking patterns, or states, that consistently recur over time across all participants. LEiDA allows for the extraction of three state-related measures which have previously been key to gaining a better understanding of brain dynamics in both healthy and clinical populations: the probability of occurrence of a given state, its lifetime and the probability of switching from one state to another. The degree to which test-retest reliability of the LEiDA measures may be affected by increasing MRI multiband (MB) factors in comparison with single band sequences is yet to be established. In this study, 24 healthy older adults were scanned over three sessions, on weeks 0, 1, and 4. On each visit, they underwent a conventional single band resting-state fMRI (rs-fMRI) scan and three different MB rs-fMRI scans, with MB factors of 4, with and without in-plane acceleration, and 6 without in-plane acceleration. We found test-retest reliability scores to be significantly higher with MB factor 4 with and without in-plane acceleration for most cortical networks. These findings will inform the choice of acquisition parameters for future studies and clinical trials.",

keywords = "brain dynamics, functional connectivity, multiband (MB), phase synchronization, reliability, resting-state, single band",

author = "Cahart, {Marie Stephanie} and Flavio Dell{\textquoteright}Acqua and Vincent Giampietro and Joana Cabral and Maarten Timmers and Johannes Streffer and Steven Einstein and Fernando Zelaya and Williams, {Steven C.R.} and Owen O{\textquoteright}Daly",

note = "Funding Information: We thank all the participants who took part in this study, as well as Janssen Research and Development (NOPRODNAP0009), a Division of Janssen Pharmaceutica NV, the Wellcome Trust/EPSRC Centre for Medical Engineering (WT 203148/Z/16/Z), the Medical Research Council Experimental Medicine Challenge Grant (MR/N026969/1), the National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre and Clinical Research Facility at South London and Maudsley NHS Foundation Trust and King{\textquoteright}s College London (IS-BRC-1215-20018), and the Portuguese Foundation for Science and Technology (UIDB/50026/2020, UIDP/50026/2020, and CEECIND/03325/2017), for their funding and ongoing support of our neuroimaging endeavors. Publisher Copyright: Copyright {\textcopyright} 2022 Cahart, Dell{\textquoteright}Acqua, Giampietro, Cabral, Timmers, Streffer, Einstein, Zelaya, Williams and O{\textquoteright}Daly.",

year = "2022",

month = nov,

day = "10",

doi = "10.3389/fnhum.2022.980280",

language = "English",

volume = "16",

journal = "Frontiers In Human Neuroscience",

issn = "1662-5161",

publisher = "Frontiers Media S.A.",

}

Cahart, MS , Dell’Acqua, F , Giampietro, V, Cabral, J, Timmers, M, Streffer, J, Einstein, S, Zelaya, F, Williams, SCR & O’Daly, O 2022, 'Test-retest reliability of time-varying patterns of brain activity across single band and multiband resting-state functional magnetic resonance imaging in healthy older adults', Frontiers In Human Neuroscience, vol. 16, 980280. https://doi.org/10.3389/fnhum.2022.980280

Test-retest reliability of time-varying patterns of brain activity across single band and multiband resting-state functional magnetic resonance imaging in healthy older adults. / Cahart, Marie Stephanie ; Dell’Acqua, Flavio ; Giampietro, Vincent et al.
In: Frontiers In Human Neuroscience, Vol. 16, 980280, 10.11.2022.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Test-retest reliability of time-varying patterns of brain activity across single band and multiband resting-state functional magnetic resonance imaging in healthy older adults

AU - Cahart, Marie Stephanie

AU - Dell’Acqua, Flavio

AU - Giampietro, Vincent

AU - Cabral, Joana

AU - Timmers, Maarten

AU - Streffer, Johannes

AU - Einstein, Steven

AU - Zelaya, Fernando

AU - Williams, Steven C.R.

AU - O’Daly, Owen

N1 - Funding Information: We thank all the participants who took part in this study, as well as Janssen Research and Development (NOPRODNAP0009), a Division of Janssen Pharmaceutica NV, the Wellcome Trust/EPSRC Centre for Medical Engineering (WT 203148/Z/16/Z), the Medical Research Council Experimental Medicine Challenge Grant (MR/N026969/1), the National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre and Clinical Research Facility at South London and Maudsley NHS Foundation Trust and King’s College London (IS-BRC-1215-20018), and the Portuguese Foundation for Science and Technology (UIDB/50026/2020, UIDP/50026/2020, and CEECIND/03325/2017), for their funding and ongoing support of our neuroimaging endeavors. Publisher Copyright: Copyright © 2022 Cahart, Dell’Acqua, Giampietro, Cabral, Timmers, Streffer, Einstein, Zelaya, Williams and O’Daly.

PY - 2022/11/10

Y1 - 2022/11/10

N2 - Leading Eigenvector Dynamics Analysis (LEiDA) is an analytic approach that characterizes brain activity recorded with functional Magnetic Resonance Imaging (fMRI) as a succession of discrete phase-locking patterns, or states, that consistently recur over time across all participants. LEiDA allows for the extraction of three state-related measures which have previously been key to gaining a better understanding of brain dynamics in both healthy and clinical populations: the probability of occurrence of a given state, its lifetime and the probability of switching from one state to another. The degree to which test-retest reliability of the LEiDA measures may be affected by increasing MRI multiband (MB) factors in comparison with single band sequences is yet to be established. In this study, 24 healthy older adults were scanned over three sessions, on weeks 0, 1, and 4. On each visit, they underwent a conventional single band resting-state fMRI (rs-fMRI) scan and three different MB rs-fMRI scans, with MB factors of 4, with and without in-plane acceleration, and 6 without in-plane acceleration. We found test-retest reliability scores to be significantly higher with MB factor 4 with and without in-plane acceleration for most cortical networks. These findings will inform the choice of acquisition parameters for future studies and clinical trials.

AB - Leading Eigenvector Dynamics Analysis (LEiDA) is an analytic approach that characterizes brain activity recorded with functional Magnetic Resonance Imaging (fMRI) as a succession of discrete phase-locking patterns, or states, that consistently recur over time across all participants. LEiDA allows for the extraction of three state-related measures which have previously been key to gaining a better understanding of brain dynamics in both healthy and clinical populations: the probability of occurrence of a given state, its lifetime and the probability of switching from one state to another. The degree to which test-retest reliability of the LEiDA measures may be affected by increasing MRI multiband (MB) factors in comparison with single band sequences is yet to be established. In this study, 24 healthy older adults were scanned over three sessions, on weeks 0, 1, and 4. On each visit, they underwent a conventional single band resting-state fMRI (rs-fMRI) scan and three different MB rs-fMRI scans, with MB factors of 4, with and without in-plane acceleration, and 6 without in-plane acceleration. We found test-retest reliability scores to be significantly higher with MB factor 4 with and without in-plane acceleration for most cortical networks. These findings will inform the choice of acquisition parameters for future studies and clinical trials.

KW - brain dynamics

KW - functional connectivity

KW - multiband (MB)

KW - phase synchronization

KW - reliability

KW - resting-state

KW - single band

UR - http://www.scopus.com/inward/record.url?scp=85142638038&partnerID=8YFLogxK

U2 - 10.3389/fnhum.2022.980280

DO - 10.3389/fnhum.2022.980280

M3 - Article

AN - SCOPUS:85142638038

SN - 1662-5161

VL - 16

JO - Frontiers In Human Neuroscience

JF - Frontiers In Human Neuroscience

M1 - 980280

ER -

Test-retest reliability of time-varying patterns of brain activity across single band and multiband resting-state functional magnetic resonance imaging in healthy older adults

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Keywords

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