TGFΒ-induced transcription in cancer

Gaia Cantelli; Eva Crosas-Molist; Mirella Georgouli; Victoria Sanz-Moreno

doi:10.1016/j.semcancer.2016.08.009

TGFΒ-induced transcription in cancer

Gaia Cantelli, Eva Crosas-Molist, Mirella Georgouli, Victoria Sanz-Moreno^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

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Abstract

The Transforming Growth Factor-beta (TGFβ) pathway mediates a broad spectrum of cellular processes and is involved in several diseases, including cancer. TGFβ has a dual role in tumours, acting as a tumour suppressor in the early phase of tumorigenesis and as a tumour promoter in more advanced stages. In this review, we discuss the effects of TGFβ-driven transcription on all stages of tumour progression, with special focus on lung cancer. Since some TGFβ target genes are specifically involved in promoting metastasis, we speculate that these genes might be good targets to block tumour progression without compromising the tumour suppressor effects of the TGFβ pathway.

Original language	English
Journal	Seminars in Cancer Biology
Early online date	30 Aug 2016
DOIs	https://doi.org/10.1016/j.semcancer.2016.08.009 https://doi.org/10.1016/j.semcancer.2016.08.009
Publication status	E-pub ahead of print - 30 Aug 2016

Keywords

Cancer
EMT
Immunosurveillance
Metastasis
TGFβ
Transcription

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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TGFΒ-induced transcription_CANTELLI_Accepted19August2016_CORRECT PROOFOther version, 2.38 MBLicence: CC BY-NC-ND

Cite this

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AU - Cantelli, Gaia

AU - Crosas-Molist, Eva

AU - Georgouli, Mirella

AU - Sanz-Moreno, Victoria

PY - 2016/8/30

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AB - The Transforming Growth Factor-beta (TGFβ) pathway mediates a broad spectrum of cellular processes and is involved in several diseases, including cancer. TGFβ has a dual role in tumours, acting as a tumour suppressor in the early phase of tumorigenesis and as a tumour promoter in more advanced stages. In this review, we discuss the effects of TGFβ-driven transcription on all stages of tumour progression, with special focus on lung cancer. Since some TGFβ target genes are specifically involved in promoting metastasis, we speculate that these genes might be good targets to block tumour progression without compromising the tumour suppressor effects of the TGFβ pathway.

KW - Cancer

KW - EMT

KW - Immunosurveillance

KW - Metastasis

KW - TGFβ

KW - Transcription

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DO - 10.1016/j.semcancer.2016.08.009

M3 - Article

SN - 1044-579X

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

ER -

TGFΒ-induced transcription in cancer

Abstract

Keywords

UN SDGs

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