The accurate relationship between spine bone density and bone marrow in humans

Xiaoguang Cheng, Kai Li, Yong Zhang, Ling Wang, Li Xu, Yandong Liu, Yangyang Duanmu, Di Chen, Wei Tian*, Glen M. Blake

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)

    Abstract

    Context: The accuracy of QCT measurements of lumbar spine trabecular volumetric bone mineral density (vBMD) is decreased due to differences in the amount of bone marrow adipose tissue (BMAT). Objective: To correct vBMD measurements for differences in marrow composition and investigate the true relationship between vBMD and BMAT. Design: Cross-sectional study. Setting: University teaching hospital. Participants: Healthy Chinese subjects (233 women, 167 men) aged between 21 and 82 years. Main outcome measures: vBMD and BMAT were measured using QCT (120 kV) and chemical shift-encoded MRI of the L2-L4 vertebrae. vBMD measurements were standardized to the European Spine Phantom (ESP) and corrected for differences in BMAT. Linear regression was used to analyze BMAT, ESP adjusted vBMD (vBMDESPcorr) and BMAT corrected vBMD (vBMDBMATcorr) against age and corrected vBMD against BMAT. Results: BMAT in the L2-L4 vertebral bodies increased with age in both sexes, with a faster rate of change in women compared with men (0.54%/year vs. 0.27%/year, P < 0.0001). After vBMD measurements were corrected for BMAT there were statistically significant changes in the slope of the regression line with age in both sexes (women: −3.00 ± 0.13 vs. −2.57 ± 0.11 mg/cm3/year, P < 0.0001; men: −1.92 ± 0.15 vs. −1.70 ± 0.14 mg/cm3/year, P < 0.0001). When vBMDBMATcorr was plotted against BMAT, vBMD decreased linearly with increasing BMAT in both sexes (women: −3.30 ± 0.18 mg/cm3/%; men: −2.69 ± 0.25 mg/cm3/%, P = 0.048). Conclusion: Our approach reveals the true relationship between vBMD and BMAT and provides a new tool for studying the interaction between bone and marrow adipose tissue.

    Original languageEnglish
    Article number115312
    JournalBone
    Volume134
    DOIs
    Publication statusPublished - May 2020

    Keywords

    • BMD
    • BMD accuracy errors
    • Bone marrow adipose tissue
    • Chemical shift encoded MRI
    • QCT

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