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The accurate relationship between spine bone density and bone marrow in humans

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The accurate relationship between spine bone density and bone marrow in humans. / Cheng, Xiaoguang; Li, Kai; Zhang, Yong; Wang, Ling; Xu, Li; Liu, Yandong; Duanmu, Yangyang; Chen, Di; Tian, Wei; Blake, Glen M.

In: Bone, Vol. 134, 115312, 05.2020.

Research output: Contribution to journalArticle

Harvard

Cheng, X, Li, K, Zhang, Y, Wang, L, Xu, L, Liu, Y, Duanmu, Y, Chen, D, Tian, W & Blake, GM 2020, 'The accurate relationship between spine bone density and bone marrow in humans', Bone, vol. 134, 115312. https://doi.org/10.1016/j.bone.2020.115312

APA

Cheng, X., Li, K., Zhang, Y., Wang, L., Xu, L., Liu, Y., ... Blake, G. M. (2020). The accurate relationship between spine bone density and bone marrow in humans. Bone, 134, [115312]. https://doi.org/10.1016/j.bone.2020.115312

Vancouver

Cheng X, Li K, Zhang Y, Wang L, Xu L, Liu Y et al. The accurate relationship between spine bone density and bone marrow in humans. Bone. 2020 May;134. 115312. https://doi.org/10.1016/j.bone.2020.115312

Author

Cheng, Xiaoguang ; Li, Kai ; Zhang, Yong ; Wang, Ling ; Xu, Li ; Liu, Yandong ; Duanmu, Yangyang ; Chen, Di ; Tian, Wei ; Blake, Glen M. / The accurate relationship between spine bone density and bone marrow in humans. In: Bone. 2020 ; Vol. 134.

Bibtex Download

@article{01eafc8456344d97be5cea6257eed044,
title = "The accurate relationship between spine bone density and bone marrow in humans",
abstract = "Context: The accuracy of QCT measurements of lumbar spine trabecular volumetric bone mineral density (vBMD) is decreased due to differences in the amount of bone marrow adipose tissue (BMAT). Objective: To correct vBMD measurements for differences in marrow composition and investigate the true relationship between vBMD and BMAT. Design: Cross-sectional study. Setting: University teaching hospital. Participants: Healthy Chinese subjects (233 women, 167 men) aged between 21 and 82 years. Main outcome measures: vBMD and BMAT were measured using QCT (120 kV) and chemical shift-encoded MRI of the L2-L4 vertebrae. vBMD measurements were standardized to the European Spine Phantom (ESP) and corrected for differences in BMAT. Linear regression was used to analyze BMAT, ESP adjusted vBMD (vBMDESPcorr) and BMAT corrected vBMD (vBMDBMATcorr) against age and corrected vBMD against BMAT. Results: BMAT in the L2-L4 vertebral bodies increased with age in both sexes, with a faster rate of change in women compared with men (0.54{\%}/year vs. 0.27{\%}/year, P < 0.0001). After vBMD measurements were corrected for BMAT there were statistically significant changes in the slope of the regression line with age in both sexes (women: −3.00 ± 0.13 vs. −2.57 ± 0.11 mg/cm3/year, P < 0.0001; men: −1.92 ± 0.15 vs. −1.70 ± 0.14 mg/cm3/year, P < 0.0001). When vBMDBMATcorr was plotted against BMAT, vBMD decreased linearly with increasing BMAT in both sexes (women: −3.30 ± 0.18 mg/cm3/{\%}; men: −2.69 ± 0.25 mg/cm3/{\%}, P = 0.048). Conclusion: Our approach reveals the true relationship between vBMD and BMAT and provides a new tool for studying the interaction between bone and marrow adipose tissue.",
keywords = "BMD, BMD accuracy errors, Bone marrow adipose tissue, Chemical shift encoded MRI, QCT",
author = "Xiaoguang Cheng and Kai Li and Yong Zhang and Ling Wang and Li Xu and Yandong Liu and Yangyang Duanmu and Di Chen and Wei Tian and Blake, {Glen M.}",
year = "2020",
month = "5",
doi = "10.1016/j.bone.2020.115312",
language = "English",
volume = "134",
journal = "Bone",
issn = "8756-3282",
publisher = "Elsevier Inc.",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - The accurate relationship between spine bone density and bone marrow in humans

AU - Cheng, Xiaoguang

AU - Li, Kai

AU - Zhang, Yong

AU - Wang, Ling

AU - Xu, Li

AU - Liu, Yandong

AU - Duanmu, Yangyang

AU - Chen, Di

AU - Tian, Wei

AU - Blake, Glen M.

PY - 2020/5

Y1 - 2020/5

N2 - Context: The accuracy of QCT measurements of lumbar spine trabecular volumetric bone mineral density (vBMD) is decreased due to differences in the amount of bone marrow adipose tissue (BMAT). Objective: To correct vBMD measurements for differences in marrow composition and investigate the true relationship between vBMD and BMAT. Design: Cross-sectional study. Setting: University teaching hospital. Participants: Healthy Chinese subjects (233 women, 167 men) aged between 21 and 82 years. Main outcome measures: vBMD and BMAT were measured using QCT (120 kV) and chemical shift-encoded MRI of the L2-L4 vertebrae. vBMD measurements were standardized to the European Spine Phantom (ESP) and corrected for differences in BMAT. Linear regression was used to analyze BMAT, ESP adjusted vBMD (vBMDESPcorr) and BMAT corrected vBMD (vBMDBMATcorr) against age and corrected vBMD against BMAT. Results: BMAT in the L2-L4 vertebral bodies increased with age in both sexes, with a faster rate of change in women compared with men (0.54%/year vs. 0.27%/year, P < 0.0001). After vBMD measurements were corrected for BMAT there were statistically significant changes in the slope of the regression line with age in both sexes (women: −3.00 ± 0.13 vs. −2.57 ± 0.11 mg/cm3/year, P < 0.0001; men: −1.92 ± 0.15 vs. −1.70 ± 0.14 mg/cm3/year, P < 0.0001). When vBMDBMATcorr was plotted against BMAT, vBMD decreased linearly with increasing BMAT in both sexes (women: −3.30 ± 0.18 mg/cm3/%; men: −2.69 ± 0.25 mg/cm3/%, P = 0.048). Conclusion: Our approach reveals the true relationship between vBMD and BMAT and provides a new tool for studying the interaction between bone and marrow adipose tissue.

AB - Context: The accuracy of QCT measurements of lumbar spine trabecular volumetric bone mineral density (vBMD) is decreased due to differences in the amount of bone marrow adipose tissue (BMAT). Objective: To correct vBMD measurements for differences in marrow composition and investigate the true relationship between vBMD and BMAT. Design: Cross-sectional study. Setting: University teaching hospital. Participants: Healthy Chinese subjects (233 women, 167 men) aged between 21 and 82 years. Main outcome measures: vBMD and BMAT were measured using QCT (120 kV) and chemical shift-encoded MRI of the L2-L4 vertebrae. vBMD measurements were standardized to the European Spine Phantom (ESP) and corrected for differences in BMAT. Linear regression was used to analyze BMAT, ESP adjusted vBMD (vBMDESPcorr) and BMAT corrected vBMD (vBMDBMATcorr) against age and corrected vBMD against BMAT. Results: BMAT in the L2-L4 vertebral bodies increased with age in both sexes, with a faster rate of change in women compared with men (0.54%/year vs. 0.27%/year, P < 0.0001). After vBMD measurements were corrected for BMAT there were statistically significant changes in the slope of the regression line with age in both sexes (women: −3.00 ± 0.13 vs. −2.57 ± 0.11 mg/cm3/year, P < 0.0001; men: −1.92 ± 0.15 vs. −1.70 ± 0.14 mg/cm3/year, P < 0.0001). When vBMDBMATcorr was plotted against BMAT, vBMD decreased linearly with increasing BMAT in both sexes (women: −3.30 ± 0.18 mg/cm3/%; men: −2.69 ± 0.25 mg/cm3/%, P = 0.048). Conclusion: Our approach reveals the true relationship between vBMD and BMAT and provides a new tool for studying the interaction between bone and marrow adipose tissue.

KW - BMD

KW - BMD accuracy errors

KW - Bone marrow adipose tissue

KW - Chemical shift encoded MRI

KW - QCT

UR - http://www.scopus.com/inward/record.url?scp=85081208591&partnerID=8YFLogxK

U2 - 10.1016/j.bone.2020.115312

DO - 10.1016/j.bone.2020.115312

M3 - Article

C2 - 32145459

AN - SCOPUS:85081208591

VL - 134

JO - Bone

JF - Bone

SN - 8756-3282

M1 - 115312

ER -

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