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The acute effects of cannabidiol on the neural correlates of reward anticipation and feedback in healthy volunteers

Research output: Contribution to journalArticle

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The acute effects of cannabidiol on the neural correlates of reward anticipation and feedback in healthy volunteers. / Lawn, Will; Hill, James; Hindocha, Chandni; Yim, Jocelyn; Yamamori, Yumeya; Jones, Gus; Walker, Hannah; Green, Sebastian F.; Wall, Matthew B.; Howes, Oliver D.; Curran, H. Valerie; Freeman, Tom P.; Bloomfield, Michael A.P.

In: Journal of Psychopharmacology, Vol. 34, No. 9, 01.09.2020, p. 969-980.

Research output: Contribution to journalArticle

Harvard

Lawn, W, Hill, J, Hindocha, C, Yim, J, Yamamori, Y, Jones, G, Walker, H, Green, SF, Wall, MB, Howes, OD, Curran, HV, Freeman, TP & Bloomfield, MAP 2020, 'The acute effects of cannabidiol on the neural correlates of reward anticipation and feedback in healthy volunteers', Journal of Psychopharmacology, vol. 34, no. 9, pp. 969-980. https://doi.org/10.1177/0269881120944148

APA

Lawn, W., Hill, J., Hindocha, C., Yim, J., Yamamori, Y., Jones, G., Walker, H., Green, S. F., Wall, M. B., Howes, O. D., Curran, H. V., Freeman, T. P., & Bloomfield, M. A. P. (2020). The acute effects of cannabidiol on the neural correlates of reward anticipation and feedback in healthy volunteers. Journal of Psychopharmacology, 34(9), 969-980. https://doi.org/10.1177/0269881120944148

Vancouver

Lawn W, Hill J, Hindocha C, Yim J, Yamamori Y, Jones G et al. The acute effects of cannabidiol on the neural correlates of reward anticipation and feedback in healthy volunteers. Journal of Psychopharmacology. 2020 Sep 1;34(9):969-980. https://doi.org/10.1177/0269881120944148

Author

Lawn, Will ; Hill, James ; Hindocha, Chandni ; Yim, Jocelyn ; Yamamori, Yumeya ; Jones, Gus ; Walker, Hannah ; Green, Sebastian F. ; Wall, Matthew B. ; Howes, Oliver D. ; Curran, H. Valerie ; Freeman, Tom P. ; Bloomfield, Michael A.P. / The acute effects of cannabidiol on the neural correlates of reward anticipation and feedback in healthy volunteers. In: Journal of Psychopharmacology. 2020 ; Vol. 34, No. 9. pp. 969-980.

Bibtex Download

@article{dd8f7db27c1845de952f26f2de54ba4d,
title = "The acute effects of cannabidiol on the neural correlates of reward anticipation and feedback in healthy volunteers",
abstract = "Background: Cannabidiol has potential therapeutic benefits for people with psychiatric disorders characterised by reward function impairment. There is existing evidence that cannabidiol may influence some aspects of reward processing. However, it is unknown whether cannabidiol acutely affects brain function underpinning reward anticipation and feedback. Hypotheses: We predicted that cannabidiol would augment brain activity associated with reward anticipation and feedback. Methods: We administered a single 600 mg oral dose of cannabidiol and matched placebo to 23 healthy participants in a double-blind, placebo-controlled, repeated-measures design. We employed the monetary incentive delay task during functional magnetic resonance imaging to assay the neural correlates of reward anticipation and feedback. We conducted whole brain analyses and region-of-interest analyses in pre-specified reward-related brain regions. Results: The monetary incentive delay task elicited expected brain activity during reward anticipation and feedback, including in the insula, caudate, nucleus accumbens, anterior cingulate and orbitofrontal cortex. However, across the whole brain, we did not find any evidence that cannabidiol altered reward-related brain activity. Moreover, our Bayesian analyses showed that activity in our regions-of-interest was similar following cannabidiol and placebo. Additionally, our behavioural measures of motivation for reward did not show a significant difference between cannabidiol and placebo. Discussion: Cannabidiol did not acutely affect the neural correlates of reward anticipation and feedback in healthy participants. Future research should explore the effects of cannabidiol on different components of reward processing, employ different doses and administration regimens, and test its reward-related effects in people with psychiatric disorders.",
keywords = "anticipation, Cannabidiol, cannabis, feedback, functional magnetic resonance imaging, marijuana, motivation, reward",
author = "Will Lawn and James Hill and Chandni Hindocha and Jocelyn Yim and Yumeya Yamamori and Gus Jones and Hannah Walker and Green, {Sebastian F.} and Wall, {Matthew B.} and Howes, {Oliver D.} and Curran, {H. Valerie} and Freeman, {Tom P.} and Bloomfield, {Michael A.P.}",
year = "2020",
month = sep,
day = "1",
doi = "10.1177/0269881120944148",
language = "English",
volume = "34",
pages = "969--980",
journal = "Journal of Psychopharmacology",
issn = "0269-8811",
publisher = "SAGE Publications Ltd STM",
number = "9",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - The acute effects of cannabidiol on the neural correlates of reward anticipation and feedback in healthy volunteers

AU - Lawn, Will

AU - Hill, James

AU - Hindocha, Chandni

AU - Yim, Jocelyn

AU - Yamamori, Yumeya

AU - Jones, Gus

AU - Walker, Hannah

AU - Green, Sebastian F.

AU - Wall, Matthew B.

AU - Howes, Oliver D.

AU - Curran, H. Valerie

AU - Freeman, Tom P.

AU - Bloomfield, Michael A.P.

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Background: Cannabidiol has potential therapeutic benefits for people with psychiatric disorders characterised by reward function impairment. There is existing evidence that cannabidiol may influence some aspects of reward processing. However, it is unknown whether cannabidiol acutely affects brain function underpinning reward anticipation and feedback. Hypotheses: We predicted that cannabidiol would augment brain activity associated with reward anticipation and feedback. Methods: We administered a single 600 mg oral dose of cannabidiol and matched placebo to 23 healthy participants in a double-blind, placebo-controlled, repeated-measures design. We employed the monetary incentive delay task during functional magnetic resonance imaging to assay the neural correlates of reward anticipation and feedback. We conducted whole brain analyses and region-of-interest analyses in pre-specified reward-related brain regions. Results: The monetary incentive delay task elicited expected brain activity during reward anticipation and feedback, including in the insula, caudate, nucleus accumbens, anterior cingulate and orbitofrontal cortex. However, across the whole brain, we did not find any evidence that cannabidiol altered reward-related brain activity. Moreover, our Bayesian analyses showed that activity in our regions-of-interest was similar following cannabidiol and placebo. Additionally, our behavioural measures of motivation for reward did not show a significant difference between cannabidiol and placebo. Discussion: Cannabidiol did not acutely affect the neural correlates of reward anticipation and feedback in healthy participants. Future research should explore the effects of cannabidiol on different components of reward processing, employ different doses and administration regimens, and test its reward-related effects in people with psychiatric disorders.

AB - Background: Cannabidiol has potential therapeutic benefits for people with psychiatric disorders characterised by reward function impairment. There is existing evidence that cannabidiol may influence some aspects of reward processing. However, it is unknown whether cannabidiol acutely affects brain function underpinning reward anticipation and feedback. Hypotheses: We predicted that cannabidiol would augment brain activity associated with reward anticipation and feedback. Methods: We administered a single 600 mg oral dose of cannabidiol and matched placebo to 23 healthy participants in a double-blind, placebo-controlled, repeated-measures design. We employed the monetary incentive delay task during functional magnetic resonance imaging to assay the neural correlates of reward anticipation and feedback. We conducted whole brain analyses and region-of-interest analyses in pre-specified reward-related brain regions. Results: The monetary incentive delay task elicited expected brain activity during reward anticipation and feedback, including in the insula, caudate, nucleus accumbens, anterior cingulate and orbitofrontal cortex. However, across the whole brain, we did not find any evidence that cannabidiol altered reward-related brain activity. Moreover, our Bayesian analyses showed that activity in our regions-of-interest was similar following cannabidiol and placebo. Additionally, our behavioural measures of motivation for reward did not show a significant difference between cannabidiol and placebo. Discussion: Cannabidiol did not acutely affect the neural correlates of reward anticipation and feedback in healthy participants. Future research should explore the effects of cannabidiol on different components of reward processing, employ different doses and administration regimens, and test its reward-related effects in people with psychiatric disorders.

KW - anticipation

KW - Cannabidiol

KW - cannabis

KW - feedback

KW - functional magnetic resonance imaging

KW - marijuana

KW - motivation

KW - reward

UR - http://www.scopus.com/inward/record.url?scp=85089190910&partnerID=8YFLogxK

U2 - 10.1177/0269881120944148

DO - 10.1177/0269881120944148

M3 - Article

C2 - 32755273

AN - SCOPUS:85089190910

VL - 34

SP - 969

EP - 980

JO - Journal of Psychopharmacology

JF - Journal of Psychopharmacology

SN - 0269-8811

IS - 9

ER -

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