The additive effect of individual genes in predicting risk of knee osteoarthritis

TY - JOUR

T1 - The additive effect of individual genes in predicting risk of knee osteoarthritis

AU - Valdes, A M

AU - Doherty, M

AU - Spector, T D

PY - 2008/1

Y1 - 2008/1

N2 - Objective: Genetic factors are important determinants of osteoarthritis ( OA) but most individual genetic associations appear relatively modest. We aimed to answer whether carrying several genetic variants associated with knee OA could result in a greater risk of OA Methods: Genotypes for 36 single nucleotide poly-morphisms ( SNPs) in 17 candidate genes previously associated with OA were analysed in 298 men and 305 women diagnosed with knee OA who met American College of Rheumatology ( ACR) criteria, and in 297 male and 299 female age- and ethnicity-matched controls. The S-sum statistic method was used to select SNPs that contributed to knee OA, separately for men and women, and the coefficients from a logistic regression were used to add the genotypes in a new genetic risk variable. Results: The odds ratio for individuals in the top quartile of the '' genetic risk'' variable compared to those in the bottom quartile was found to be 8.68 ( 95% Cl 5.20-14.49, p

AB - Objective: Genetic factors are important determinants of osteoarthritis ( OA) but most individual genetic associations appear relatively modest. We aimed to answer whether carrying several genetic variants associated with knee OA could result in a greater risk of OA Methods: Genotypes for 36 single nucleotide poly-morphisms ( SNPs) in 17 candidate genes previously associated with OA were analysed in 298 men and 305 women diagnosed with knee OA who met American College of Rheumatology ( ACR) criteria, and in 297 male and 299 female age- and ethnicity-matched controls. The S-sum statistic method was used to select SNPs that contributed to knee OA, separately for men and women, and the coefficients from a logistic regression were used to add the genotypes in a new genetic risk variable. Results: The odds ratio for individuals in the top quartile of the '' genetic risk'' variable compared to those in the bottom quartile was found to be 8.68 ( 95% Cl 5.20-14.49, p

U2 - 10.1136/ard.2007.075838

DO - 10.1136/ard.2007.075838

M3 - Article

SN - 1468-2060

VL - 67

SP - 124

EP - 127

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

IS - 1

ER -