TY - JOUR
T1 - The Additive Value of Cardiovascular Magnetic Resonance in Convalescent COVID-19 Patients
AU - Borlotti, Alessandra
AU - Thomaides-Brears, Helena
AU - Georgiopoulos, Georgios
AU - Banerjee, Rajarshi
AU - Robson, Matthew D.
AU - Fusco, Dahlene N.
AU - Masci, Pier Giorgio
N1 - Publisher Copyright:
Copyright © 2022 Borlotti, Thomaides-Brears, Georgiopoulos, Banerjee, Robson, Fusco and Masci.
PY - 2022/4/7
Y1 - 2022/4/7
N2 - In COVID-19 the development of severe viral pneumonia that is coupled with systemic inflammatory response triggers multi-organ failure and is of major concern. Cardiac involvement occurs in nearly 60% of patients with pre-existing cardiovascular conditions and heralds worse clinical outcome. Diagnoses carried out in the acute phase of COVID-19 rely upon increased levels of circulating cardiac injury biomarkers and transthoracic echocardiography. These diagnostics, however, were unable to pinpoint the mechanisms of cardiac injury in COVID-19 patients. Identifying the main features of cardiac injury remains an urgent yet unmet need in cardiology, given the potential clinical consequences. Cardiovascular magnetic resonance (CMR) provides an unparalleled opportunity to gain a deeper insight into myocardial injury given its unique ability to interrogate the properties of myocardial tissue. This endeavor is particularly important in convalescent COVID-19 patients as many continue to experience chest pain, palpitations, dyspnea and exertional fatigue, six or more months after the acute illness. This review will provide a critical appraisal of research on cardiovascular damage in convalescent adult COVID-19 patients with an emphasis on the use of CMR and its value to our understanding of organ damage.
AB - In COVID-19 the development of severe viral pneumonia that is coupled with systemic inflammatory response triggers multi-organ failure and is of major concern. Cardiac involvement occurs in nearly 60% of patients with pre-existing cardiovascular conditions and heralds worse clinical outcome. Diagnoses carried out in the acute phase of COVID-19 rely upon increased levels of circulating cardiac injury biomarkers and transthoracic echocardiography. These diagnostics, however, were unable to pinpoint the mechanisms of cardiac injury in COVID-19 patients. Identifying the main features of cardiac injury remains an urgent yet unmet need in cardiology, given the potential clinical consequences. Cardiovascular magnetic resonance (CMR) provides an unparalleled opportunity to gain a deeper insight into myocardial injury given its unique ability to interrogate the properties of myocardial tissue. This endeavor is particularly important in convalescent COVID-19 patients as many continue to experience chest pain, palpitations, dyspnea and exertional fatigue, six or more months after the acute illness. This review will provide a critical appraisal of research on cardiovascular damage in convalescent adult COVID-19 patients with an emphasis on the use of CMR and its value to our understanding of organ damage.
KW - cardiovascular magnetic resonanace
KW - convalescent COVID-19 patients
KW - long-COVID
KW - multi-organ damage
KW - myocardial injury
UR - http://www.scopus.com/inward/record.url?scp=85138546844&partnerID=8YFLogxK
U2 - 10.3389/fcvm.2022.854750
DO - 10.3389/fcvm.2022.854750
M3 - Review article
AN - SCOPUS:85138546844
SN - 2297-055X
VL - 9
JO - Frontiers in Cardiovascular Medicine
JF - Frontiers in Cardiovascular Medicine
M1 - 854750
ER -
