The additive value of three-dimensional derived left atrial volume and carotid imaging in dobutamine stress echocardiography

Vasileios Sachpekidis, Amit Bhan, Matthias Paul, Silvia Gianstefani, Lindsay Smith, Joseph Reiken, Nicola Walker, Derek Harries, Peter Pearson, Mark J. Monaghan

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2 Citations (Scopus)


Aims To evaluate whether the three-dimensional (3D) left atrial volume index (LAVI) and/or the presence of carotid plaques (CP) can predict the result of dobutamine stress echocardiography (DSE), thereby aiding interpretation. Methods and results We studied 130 patients (52 male, mean age 63 +/- 11 years) with normal resting wall motion (WM) undergoing DSE. All patients had the end-systolic 2D and 3D LAVI measured, as well as bilateral carotid scanning. DSE was reported as abnormal in 50 (38.5%) patients. 3D end-systolic LAVI measurements were significantly higher (31.5 +/- 8.2 vs 27.4 +/- 7.4 mL/m(2), P = 0.004) in those with an abnormal DSE. The two groups did not differ significantly on the 2D derived maximum LAVI measurements (36.2 +/- 9.5 vs 34.2 +/- 11.2, P = 0.299) and the presence of plaques in the carotid arteries (89.1 vs. 76.2%, P = 0.100). Receiver operating characteristic curves were created to define cut-offs that could predict the DSE result for the 3D LAVI. A 3D LAVI of >24.5 mL/m(2) had a sensitivity of 80% for predicting an abnormal DSE, whereas a value of >36.0 mL/m(2) had a specificity of 93% for the same cause. Intra-observer (r = 0.997, P <0.0001) and inter-observer (r = 0.961, P <0.0001) variability for 3D LAVI measurements was found to be excellent. Conclusion Three-dimensional (but not 2D) assessment of LAVI may offer additional information in predicting the result of DSE. Carotid scanning did not offer additional information for the same cause.
Original languageEnglish
Pages (from-to)46 - 53
Number of pages8
JournalEuropean Journal of Echocardiography
Issue number1
Early online date8 Sept 2010
Publication statusPublished - Jan 2011


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