TY - JOUR
T1 - The adverse effects of an excessive folic acid intake
AU - Patel, K. R.
AU - Sobczyńska-Malefora, A.
PY - 2016/10/12
Y1 - 2016/10/12
N2 - Folate is a vital component of a healthy diet, being essential for numerous bodily functions. Deficiency of folate is common, with studies suggesting prevalence of deficiencyas high as 85.5% as was shown in women between the ages of 16 and 49, living in the UK. Causes of folate deficiency range from diet and lifestyle, to pathological and pharmacological processes. Because of the well-known role of folate in prevention of neural tube defects, numerous countries have implemented strategies to increase folate intake, with programs such as mandatory grain fortification. As a result, the intake of folate in these countries is often higher than the recommended dietary allowance for many groups of people. Although folate is believed to be non-toxic, the potential adverse effects of excessive intake of folic acid (synthetic form of folate) have not been highlighted well by authorities to people taking supplements; despite this, many studies have addressed this issue. However, the results of these studies provide discrepant results, leading to confusion as to whether mandatory folic acid fortification should be introduced in other countries. The purpose of this review was to provide a summary of evidence related to high folic acid ingestion and to look at the unwanted effects it may have on the certain groups within the general population.European Journal of Clinical Nutrition advance online publication, 12 October 2016; doi:10.1038/ejcn.2016.194.
AB - Folate is a vital component of a healthy diet, being essential for numerous bodily functions. Deficiency of folate is common, with studies suggesting prevalence of deficiencyas high as 85.5% as was shown in women between the ages of 16 and 49, living in the UK. Causes of folate deficiency range from diet and lifestyle, to pathological and pharmacological processes. Because of the well-known role of folate in prevention of neural tube defects, numerous countries have implemented strategies to increase folate intake, with programs such as mandatory grain fortification. As a result, the intake of folate in these countries is often higher than the recommended dietary allowance for many groups of people. Although folate is believed to be non-toxic, the potential adverse effects of excessive intake of folic acid (synthetic form of folate) have not been highlighted well by authorities to people taking supplements; despite this, many studies have addressed this issue. However, the results of these studies provide discrepant results, leading to confusion as to whether mandatory folic acid fortification should be introduced in other countries. The purpose of this review was to provide a summary of evidence related to high folic acid ingestion and to look at the unwanted effects it may have on the certain groups within the general population.European Journal of Clinical Nutrition advance online publication, 12 October 2016; doi:10.1038/ejcn.2016.194.
UR - http://www.scopus.com/inward/record.url?scp=84991030569&partnerID=8YFLogxK
U2 - 10.1038/ejcn.2016.194
DO - 10.1038/ejcn.2016.194
M3 - Article
AN - SCOPUS:84991030569
SN - 0954-3007
SP - 1
EP - 5
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
ER -