The Application of In Vivo MRI and MRS in Phenomic Studies of Murine Models of Disease

Po-Wah So; Azhaar Ahmad Ashraf; Alice Marie Sybille Durieux; William R. Crum; Jimmy Bell

The Application of In Vivo MRI and MRS in Phenomic Studies of Murine Models of Disease

Po-Wah So, Azhaar Ahmad Ashraf, Alice Marie Sybille Durieux, William R. Crum, Jimmy Bell

Neuroimaging

University of Westminster

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

As we enter the post-genomic era, understanding the role and function of single or group of genes in the context of a whole functioning organism, has become paramount in terms of human health. Much of this work is being carried out in rodent models of diseases, requiring the use of in vivo non-invasive imaging techniques to study the animals. Here we review the use of magnetic resonance imaging (MRI) and multi-nuclear magnetic resonance spectroscopy (MRS) for the phenotypic characterization of the ever increasing numbers of murine models of health and disease. We describe the current MRI and MRS strategies being applied to the characterization of these models and point out potential pitfalls and limitations of the available techniques. Finally, we review the latest advances in MRI and MRS and their potential application to pre-clinical studies.

Original language	English
Title of host publication	The Application of In Vivo MRI and MRS in Phenomic Studies of Murine Models of Disease
Editors	G Webb
Place of Publication	Cham
Publisher	Springer
Chapter	2
Volume	1
Edition	2
ISBN (Electronic)	978-3-319-28388-3
ISBN (Print)	978-3-319-28387-6
Publication status	Published - 1 Jun 2018

Keywords

Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Phenotyping
MURINE MODELS
models of disease

Cite this

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title = "The Application of In Vivo MRI and MRS in Phenomic Studies of Murine Models of Disease",

abstract = "As we enter the post-genomic era, understanding the role and function of single or group of genes in the context of a whole functioning organism, has become paramount in terms of human health. Much of this work is being carried out in rodent models of diseases, requiring the use of in vivo non-invasive imaging techniques to study the animals. Here we review the use of magnetic resonance imaging (MRI) and multi-nuclear magnetic resonance spectroscopy (MRS) for the phenotypic characterization of the ever increasing numbers of murine models of health and disease. We describe the current MRI and MRS strategies being applied to the characterization of these models and point out potential pitfalls and limitations of the available techniques. Finally, we review the latest advances in MRI and MRS and their potential application to pre-clinical studies.",

keywords = "Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Phenotyping, MURINE MODELS, models of disease",

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The Application of In Vivo MRI and MRS in Phenomic Studies of Murine Models of Disease. / So, Po-Wah ; Ashraf, Azhaar Ahmad ; Durieux, Alice Marie Sybille et al.
The Application of In Vivo MRI and MRS in Phenomic Studies of Murine Models of Disease. ed. / G Webb. Vol. 1 2. ed. Cham: Springer, 2018.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

TY - CHAP

T1 - The Application of In Vivo MRI and MRS in Phenomic Studies of Murine Models of Disease

AU - So, Po-Wah

AU - Ashraf, Azhaar Ahmad

AU - Durieux, Alice Marie Sybille

AU - Crum, William R.

AU - Bell, Jimmy

PY - 2018/6/1

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N2 - As we enter the post-genomic era, understanding the role and function of single or group of genes in the context of a whole functioning organism, has become paramount in terms of human health. Much of this work is being carried out in rodent models of diseases, requiring the use of in vivo non-invasive imaging techniques to study the animals. Here we review the use of magnetic resonance imaging (MRI) and multi-nuclear magnetic resonance spectroscopy (MRS) for the phenotypic characterization of the ever increasing numbers of murine models of health and disease. We describe the current MRI and MRS strategies being applied to the characterization of these models and point out potential pitfalls and limitations of the available techniques. Finally, we review the latest advances in MRI and MRS and their potential application to pre-clinical studies.

AB - As we enter the post-genomic era, understanding the role and function of single or group of genes in the context of a whole functioning organism, has become paramount in terms of human health. Much of this work is being carried out in rodent models of diseases, requiring the use of in vivo non-invasive imaging techniques to study the animals. Here we review the use of magnetic resonance imaging (MRI) and multi-nuclear magnetic resonance spectroscopy (MRS) for the phenotypic characterization of the ever increasing numbers of murine models of health and disease. We describe the current MRI and MRS strategies being applied to the characterization of these models and point out potential pitfalls and limitations of the available techniques. Finally, we review the latest advances in MRI and MRS and their potential application to pre-clinical studies.

KW - Magnetic Resonance Imaging

KW - Magnetic Resonance Spectroscopy

KW - Phenotyping

KW - MURINE MODELS

KW - models of disease

M3 - Chapter

SN - 978-3-319-28387-6

VL - 1

BT - The Application of In Vivo MRI and MRS in Phenomic Studies of Murine Models of Disease

A2 - Webb, G

PB - Springer

CY - Cham

ER -

The Application of In Vivo MRI and MRS in Phenomic Studies of Murine Models of Disease

Abstract

Keywords

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