Abstract
The genomic revolution has rapidly expanded in recent years from unravelling the human genome to sequencing the genome of many other species, including, mice, insects, and plants. Determining the role of individual genes in the pathophysiology of many human and animal diseases has now become a reality. A variety of in vitro methods have been developed to assess gene expression at both the cellular and organ levels, allowing ever increasing understanding of the genetic control of disease development. However, it has also become clear that to fully understand the role of many genes in health and disease, it is necessary to determine their function in the context of a whole functioning organism. Indeed, a number of studies have recently shown that the relative expression of some candidate genes is significantly modulated not only by environmental factors but also by the genetic background of the organism [1]. However, the currently available in vitro techniques cannot be readily applied to developmental or longitudinal studies, thus limiting their usefulness in elucidating gene expression and function.
| Original language | English |
|---|---|
| Title of host publication | Modern Magnetic Resonance |
| Editors | Graham Webb |
| Place of Publication | The Netherlands |
| Publisher | Springer |
| Pages | 769-785 |
| Volume | Part 1 |
| Edition | 1st edition |
| ISBN (Electronic) | 978-1-4020-3910-2 |
| ISBN (Print) | 978-1-4020-3894-5 |
| Publication status | Published - 2006 |