The association of lumbar disc herniation with lumbar volumetric bone mineral density in a cross-sectional chinese study

Jian Geng; Ling Wang; Qing Li; Pengju Huang; Yandong Liu; Glen M. Blake; Wei Tian; Xiaoguang Cheng

doi:10.3390/diagnostics11060938

The association of lumbar disc herniation with lumbar volumetric bone mineral density in a cross-sectional chinese study

Jian Geng, Ling Wang, Qing Li, Pengju Huang, Yandong Liu, Glen M. Blake, Wei Tian, Xiaoguang Cheng^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Little is known about the effect of lumbar intervertebral disc herniation (LDH) on lumbar bone mineral density (BMD), and few previous studies have used quantitative computed tomography (QCT) to assess whether the staging of LDH correlates with lumbar vertebral trabecular volumetric bone mineral density (Trab.vBMD). To explore the relationship between lumbar Trab.vBMD and LDH, seven hundred and fifty-four healthy participants aged 20–60 years were enrolled in the study from an ongoing study on the degeneration of the spine and knee between June 2014 and 2017. QCT was used to measure L2–4 Trab.vBMD and lumbar spine magnetic resonance images (MRI) were performed to assess the incidence of disc herniation. After 9 exclusions, a total of 322 men and 423 women remained. The men and women were divided into younger (age 20–39 years) and older (age 40–60 years) groups and further into those without LDH, with a single LDH segment, and with ≥2 segments. Covariance analysis was used to adjust for the effects of age, BMI, waistline, and hipline on the relationship between Trab.vBMD and LDH. Forty-one younger men (25.0%) and 59 older men (37.3%) had at least one LDH segment. Amongst the women, the numbers were 46 (22.5%) and 80 (36.4%), respectively. Although there were differences in the characteristics data between men and women, the difference in Trab.vBMD between those without LDH and those with single and ≥2 segments was not statistically significant (p > 0.05). These results remained not statistically significant after further adjusting for covariates (p > 0.05). No associations between lumbar disc herniation and vertebral trabecular volumetric bone mineral density were observed in either men or women.

Original language	English
Article number	938
Journal	Diagnostics
Volume	11
Issue number	6
DOIs	https://doi.org/10.3390/diagnostics11060938
Publication status	Published - Jun 2021

Keywords

Lumbar intervertebral disc herniation
Lumbar volumetric bone mineral density

Access to Document

10.3390/diagnostics11060938

Cite this

@article{f9fd4fa86bae4f8ea338c9826296e6bb,

title = "The association of lumbar disc herniation with lumbar volumetric bone mineral density in a cross-sectional chinese study",

abstract = "Little is known about the effect of lumbar intervertebral disc herniation (LDH) on lumbar bone mineral density (BMD), and few previous studies have used quantitative computed tomography (QCT) to assess whether the staging of LDH correlates with lumbar vertebral trabecular volumetric bone mineral density (Trab.vBMD). To explore the relationship between lumbar Trab.vBMD and LDH, seven hundred and fifty-four healthy participants aged 20–60 years were enrolled in the study from an ongoing study on the degeneration of the spine and knee between June 2014 and 2017. QCT was used to measure L2–4 Trab.vBMD and lumbar spine magnetic resonance images (MRI) were performed to assess the incidence of disc herniation. After 9 exclusions, a total of 322 men and 423 women remained. The men and women were divided into younger (age 20–39 years) and older (age 40–60 years) groups and further into those without LDH, with a single LDH segment, and with ≥2 segments. Covariance analysis was used to adjust for the effects of age, BMI, waistline, and hipline on the relationship between Trab.vBMD and LDH. Forty-one younger men (25.0%) and 59 older men (37.3%) had at least one LDH segment. Amongst the women, the numbers were 46 (22.5%) and 80 (36.4%), respectively. Although there were differences in the characteristics data between men and women, the difference in Trab.vBMD between those without LDH and those with single and ≥2 segments was not statistically significant (p > 0.05). These results remained not statistically significant after further adjusting for covariates (p > 0.05). No associations between lumbar disc herniation and vertebral trabecular volumetric bone mineral density were observed in either men or women.",

keywords = "Lumbar intervertebral disc herniation, Lumbar volumetric bone mineral density",

author = "Jian Geng and Ling Wang and Qing Li and Pengju Huang and Yandong Liu and Blake, {Glen M.} and Wei Tian and Xiaoguang Cheng",

note = "Funding Information: This work is supported by Beijing Hospitals Authority Clinical Medicine Development of Special Funding (ZYLX202107). And The APC was funded by [ZYLX202107]. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = jun,

doi = "10.3390/diagnostics11060938",

language = "English",

volume = "11",

journal = "Diagnostics",

issn = "2075-4418",

publisher = "Dental materials in vivo : Aging and related phenomena. George Eliades, Theodore Eliades, William A Brantley & David C Watts. Quintessence Publishing Co Ltd, ISBN 0-86715-399-7. Br Dent J",

number = "6",

}

TY - JOUR

T1 - The association of lumbar disc herniation with lumbar volumetric bone mineral density in a cross-sectional chinese study

AU - Geng, Jian

AU - Wang, Ling

AU - Li, Qing

AU - Huang, Pengju

AU - Liu, Yandong

AU - Blake, Glen M.

AU - Tian, Wei

AU - Cheng, Xiaoguang

N1 - Funding Information: This work is supported by Beijing Hospitals Authority Clinical Medicine Development of Special Funding (ZYLX202107). And The APC was funded by [ZYLX202107]. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/6

Y1 - 2021/6

N2 - Little is known about the effect of lumbar intervertebral disc herniation (LDH) on lumbar bone mineral density (BMD), and few previous studies have used quantitative computed tomography (QCT) to assess whether the staging of LDH correlates with lumbar vertebral trabecular volumetric bone mineral density (Trab.vBMD). To explore the relationship between lumbar Trab.vBMD and LDH, seven hundred and fifty-four healthy participants aged 20–60 years were enrolled in the study from an ongoing study on the degeneration of the spine and knee between June 2014 and 2017. QCT was used to measure L2–4 Trab.vBMD and lumbar spine magnetic resonance images (MRI) were performed to assess the incidence of disc herniation. After 9 exclusions, a total of 322 men and 423 women remained. The men and women were divided into younger (age 20–39 years) and older (age 40–60 years) groups and further into those without LDH, with a single LDH segment, and with ≥2 segments. Covariance analysis was used to adjust for the effects of age, BMI, waistline, and hipline on the relationship between Trab.vBMD and LDH. Forty-one younger men (25.0%) and 59 older men (37.3%) had at least one LDH segment. Amongst the women, the numbers were 46 (22.5%) and 80 (36.4%), respectively. Although there were differences in the characteristics data between men and women, the difference in Trab.vBMD between those without LDH and those with single and ≥2 segments was not statistically significant (p > 0.05). These results remained not statistically significant after further adjusting for covariates (p > 0.05). No associations between lumbar disc herniation and vertebral trabecular volumetric bone mineral density were observed in either men or women.

AB - Little is known about the effect of lumbar intervertebral disc herniation (LDH) on lumbar bone mineral density (BMD), and few previous studies have used quantitative computed tomography (QCT) to assess whether the staging of LDH correlates with lumbar vertebral trabecular volumetric bone mineral density (Trab.vBMD). To explore the relationship between lumbar Trab.vBMD and LDH, seven hundred and fifty-four healthy participants aged 20–60 years were enrolled in the study from an ongoing study on the degeneration of the spine and knee between June 2014 and 2017. QCT was used to measure L2–4 Trab.vBMD and lumbar spine magnetic resonance images (MRI) were performed to assess the incidence of disc herniation. After 9 exclusions, a total of 322 men and 423 women remained. The men and women were divided into younger (age 20–39 years) and older (age 40–60 years) groups and further into those without LDH, with a single LDH segment, and with ≥2 segments. Covariance analysis was used to adjust for the effects of age, BMI, waistline, and hipline on the relationship between Trab.vBMD and LDH. Forty-one younger men (25.0%) and 59 older men (37.3%) had at least one LDH segment. Amongst the women, the numbers were 46 (22.5%) and 80 (36.4%), respectively. Although there were differences in the characteristics data between men and women, the difference in Trab.vBMD between those without LDH and those with single and ≥2 segments was not statistically significant (p > 0.05). These results remained not statistically significant after further adjusting for covariates (p > 0.05). No associations between lumbar disc herniation and vertebral trabecular volumetric bone mineral density were observed in either men or women.

KW - Lumbar intervertebral disc herniation

KW - Lumbar volumetric bone mineral density

UR - http://www.scopus.com/inward/record.url?scp=85107436152&partnerID=8YFLogxK

U2 - 10.3390/diagnostics11060938

DO - 10.3390/diagnostics11060938

M3 - Article

AN - SCOPUS:85107436152

SN - 2075-4418

VL - 11

JO - Diagnostics

JF - Diagnostics

IS - 6

M1 - 938

ER -

The association of lumbar disc herniation with lumbar volumetric bone mineral density in a cross-sectional chinese study

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this