The association of white matter volume in psychotic disorders with genotypic variation in NRG1, MOG and CNP: a voxel-based analysis in affected individuals and their unaffected relatives

D. M. Cannon*, M. Walshe, E. Dempster, D. A. Collier, N. Marshall, Elvira Bramon-Bosch, R. M. Murray, C. McDonald

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

We investigated the role of variation in putative psychosis genes coding for elements of the white matter system by examining the contribution of genotypic variation in three single-nucleotide polymorphisms (SNPs) neuregulin 1 (NRG1) SNP8NRG221533, myelin oligodendrocytes glycoprotein (MOG) rs2857766 and CNP (rs2070106) and one haplotype HAP(ICE) (deCODE) to white matter volume in patients with psychotic disorder and their unaffected relatives. Structural magnetic resonance imaging and blood samples for genotyping were collected on 189 participants including patients with schizophrenia (SZ) or bipolar I disorder (BDI), unaffected first-degree relatives of these patients and healthy volunteers. The association of genotypic variation with white matter volume was assessed using voxel-based morphometry in SPM5. The NRG1 SNP and the HAP(ICE) haplotype were associated with abnormal white matter volume in the BDI group in the fornix, cingulum and parahippocampal gyrus circuit. In SZ the NRG1 SNP risk allele was associated with lower white matter volume in the uncinate fasciculus (UF), right inferior longitudinal fasciculus and the anterior limb of the internal capsule. Healthy G-homozygotes of the MOG SNP had greater white matter volume in areas of the brainstem and cerebellum; this relationship was absent in those with a psychotic disorder and the unaffected relatives groups. The CNP SNP did not contribute to white matter volume variation in the diagnostic groups studied. Variation in the genes coding for structural and protective components of myelin are implicated in abnormal white matter volume in the emotion circuitry of the cingulum, fornix, parahippocampal gyrus and UF in psychotic disorders. Translational Psychiatry (2012) 2, e167; doi:10.1038/tp.2012.82; published online 9 October 2012

Original languageEnglish
Article numbere167
Number of pages9
JournalTranslational psychiatry
Volume2
DOIs
Publication statusPublished - Oct 2012

Keywords

  • CNP
  • HAP(ICE)
  • MOG
  • NRG1
  • voxel-based morphometry
  • white matter
  • 2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE
  • NONFAMILIAL SCHIZOPHRENIC PROBANDS
  • DORSOLATERAL PREFRONTAL CORTEX
  • ANTERIOR CINGULATE CORTEX
  • MYELINATION-RELATED GENES
  • FAMILY-BASED ASSOCIATION
  • BIPOLAR DISORDER
  • GENOME SCAN
  • OLIGODENDROGLIAL ABNORMALITIES
  • SUSCEPTIBILITY LOCI

Fingerprint

Dive into the research topics of 'The association of white matter volume in psychotic disorders with genotypic variation in NRG1, MOG and CNP: a voxel-based analysis in affected individuals and their unaffected relatives'. Together they form a unique fingerprint.

Cite this