The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches

Annika Brosig, Joachim Fuchs, Fatih Ipek, Cristina Kroon, Sandra Schrötter, Mayur Vadhvani, Alexandra Polyzou, Julia Ledderose, Michiel van Diepen, Hermann Georg Holzhütter, Thorsten Trimbuch, Niclas Gimber, Jan Schmoranzer, Ivo Lieberam, Christian Rosenmund, Christian Spahn, Patrick Scheerer, Michal Szczepek, George Leondaritis*, Britta J. Eickholt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

PTEN globally suppresses growth in multiple cell types and inhibits neuronal axon growth and branching. Brosig et al. describe a mechanism for developing neurons to inhibit PTEN function by upregulating PRG2 in the axon. Although the overall growth capacity of neurons remains constant, PRG2 redirects growth to axon branches.

Original languageEnglish
Pages (from-to)2028-2040.e8
JournalCell Reports
Volume29
Issue number7
DOIs
Publication statusPublished - 12 Nov 2019

Keywords

  • axon morphogenesis
  • branching
  • neuronal growth homeostasis
  • phosphoinositide signaling
  • PI3K signaling
  • plasticity-related gene family
  • PTEN

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