The bio-exposome: intracellular processes, stress physiology and the environment

Helen Minnis; Anne Laura Van Harmelen; Ruchika Gajwani; Jala Rizeq; Emilie Combet; Rebecca Reynolds; Christopher Gillberg; Marion Henderson; Fred Ho; Valeria Mondelli; Jill Pell; Joanne Smith; Paul Shiels

doi:10.1038/s44220-023-00180-3

The bio-exposome: intracellular processes, stress physiology and the environment

Helen Minnis, Anne Laura Van Harmelen, Ruchika Gajwani, Jala Rizeq, Emilie Combet, Rebecca Reynolds, Christopher Gillberg, Marion Henderson, Fred Ho, Valeria Mondelli, Jill Pell, Joanne Smith, Paul Shiels

University of Glasgow

Research output: Contribution to journal › Article › peer-review

Abstract

Most studies on the relationship between childhood adversity and negative outcomes across the lifespan have focused on individual exposures or outcomes—an approach that has been limited in its ability to elucidate mechanisms or causality. We propose a new framework for examining the relationship between childhood adversity and negative outcomes—the bio-exposome. In this model, we aim to understand the interconnections between every aspect of biology and the exposome, and the way disparate biological and exposome factors shape, and are shaped by, one another. Once we understand when, in which contexts and towards whom stress calibration interventions should be targeted, through examination of the bio-exposome, we could facilitate prevention of some of the major causes of morbidity across the lifespan. To examine the bio-exposome, we offer a new research agenda that embraces complexity science, large datasets and collaboration across a wide range of scientific disciplines.

Original language	English
Journal	Nature Mental Health
Early online date	9 Feb 2024
DOIs	https://doi.org/10.1038/s44220-023-00180-3
Publication status	E-pub ahead of print - 9 Feb 2024

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BioExposome_paper
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Cite this

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title = "The bio-exposome: intracellular processes, stress physiology and the environment",

abstract = "Most studies on the relationship between childhood adversity and negative outcomes across the lifespan have focused on individual exposures or outcomes—an approach that has been limited in its ability to elucidate mechanisms or causality. We propose a new framework for examining the relationship between childhood adversity and negative outcomes—the bio-exposome. In this model, we aim to understand the interconnections between every aspect of biology and the exposome, and the way disparate biological and exposome factors shape, and are shaped by, one another. Once we understand when, in which contexts and towards whom stress calibration interventions should be targeted, through examination of the bio-exposome, we could facilitate prevention of some of the major causes of morbidity across the lifespan. To examine the bio-exposome, we offer a new research agenda that embraces complexity science, large datasets and collaboration across a wide range of scientific disciplines.",

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T2 - intracellular processes, stress physiology and the environment

AU - Minnis, Helen

AU - Van Harmelen, Anne Laura

AU - Gajwani, Ruchika

AU - Rizeq, Jala

AU - Combet, Emilie

AU - Reynolds, Rebecca

AU - Gillberg, Christopher

AU - Henderson, Marion

AU - Ho, Fred

AU - Mondelli, Valeria

AU - Pell, Jill

AU - Smith, Joanne

AU - Shiels, Paul

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AB - Most studies on the relationship between childhood adversity and negative outcomes across the lifespan have focused on individual exposures or outcomes—an approach that has been limited in its ability to elucidate mechanisms or causality. We propose a new framework for examining the relationship between childhood adversity and negative outcomes—the bio-exposome. In this model, we aim to understand the interconnections between every aspect of biology and the exposome, and the way disparate biological and exposome factors shape, and are shaped by, one another. Once we understand when, in which contexts and towards whom stress calibration interventions should be targeted, through examination of the bio-exposome, we could facilitate prevention of some of the major causes of morbidity across the lifespan. To examine the bio-exposome, we offer a new research agenda that embraces complexity science, large datasets and collaboration across a wide range of scientific disciplines.

U2 - 10.1038/s44220-023-00180-3

DO - 10.1038/s44220-023-00180-3

M3 - Article

SN - 2731-6076

JO - Nature Mental Health

JF - Nature Mental Health

ER -

The bio-exposome: intracellular processes, stress physiology and the environment

Abstract

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