The Bipolar Association Case-Control Study (BACCS) and meta-analysis: No association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder

Sarah Cohen-Woods; Ian Craig; Darya Gaysina; Joanna Gray; Cerisse Gunasinghe; Nick Craddock; Amanda Elkin; Lisa Jones; James Kennedy; Nicole King; Ania Korszun; Jo Knight; Michael Owen; Sagar Parikh; John Strauss; Abram Sterne; Federica Tozzi; Julia Perry; Pierandrea Muglia; John Vincent; Peter McGuffin; Anne Farmer

doi:10.1002/ajmg.b.31101

The Bipolar Association Case-Control Study (BACCS) and meta-analysis: No association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder

Sarah Cohen-Woods, Ian Craig, Darya Gaysina, Joanna Gray, Cerisse Gunasinghe, Nick Craddock, Amanda Elkin, Lisa Jones, James Kennedy, Nicole King, Ania Korszun, Jo Knight, Michael Owen, Sagar Parikh, John Strauss, Abram Sterne, Federica Tozzi, Julia Perry, Pierandrea Muglia, John VincentPeter McGuffin, Anne Farmer

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Bipolar disorder (BD) is a complex genetic disease for which the underlying pathophysiology has yet to be fully explained. 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. A single base variant in MTHFR gene (C677T) results in the production of a mildly dysfunctional thermolabile enzyme and has recently been implicated in BD. We conducted an association study of this polymorphism in 897 patients with bipolar I or bipolar II disorder, and 1,687 healthy control subjects. We found no evidence for genotypic or allelic association in this sample. We also performed a meta-analysis of our own, and all published data, and report no evidence for association. Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD.

Original language	English
Pages (from-to)	1298 - 1304
Number of pages	7
Journal	American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Volume	153B
Issue number	7
DOIs	https://doi.org/10.1002/ajmg.b.31101
Publication status	Published - Oct 2010

Keywords

Alleles
Bipolar Disorder/epidemiology
Case-Control Studies
Genetic Association Studies/methods
Genotype
Humans
Methylenetetrahydrofolate Reductase (NADPH2)/genetics
Polymorphism, Single Nucleotide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ajmg.b.31101

Cite this

Cohen-Woods, S., Craig, I., Gaysina, D., Gray, J., Gunasinghe, C., Craddock, N., Elkin, A., Jones, L., Kennedy, J., King, N., Korszun, A., Knight, J., Owen, M., Parikh, S., Strauss, J., Sterne, A., Tozzi, F., Perry, J., Muglia, P., ... Farmer, A. (2010). The Bipolar Association Case-Control Study (BACCS) and meta-analysis: No association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 153B(7), 1298 - 1304. https://doi.org/10.1002/ajmg.b.31101

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title = "The Bipolar Association Case-Control Study (BACCS) and meta-analysis: No association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder",

abstract = "Bipolar disorder (BD) is a complex genetic disease for which the underlying pathophysiology has yet to be fully explained. 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. A single base variant in MTHFR gene (C677T) results in the production of a mildly dysfunctional thermolabile enzyme and has recently been implicated in BD. We conducted an association study of this polymorphism in 897 patients with bipolar I or bipolar II disorder, and 1,687 healthy control subjects. We found no evidence for genotypic or allelic association in this sample. We also performed a meta-analysis of our own, and all published data, and report no evidence for association. Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD.",

keywords = "Alleles, Bipolar Disorder/epidemiology, Case-Control Studies, Genetic Association Studies/methods, Genotype, Humans, Methylenetetrahydrofolate Reductase (NADPH2)/genetics, Polymorphism, Single Nucleotide",

author = "Sarah Cohen-Woods and Ian Craig and Darya Gaysina and Joanna Gray and Cerisse Gunasinghe and Nick Craddock and Amanda Elkin and Lisa Jones and James Kennedy and Nicole King and Ania Korszun and Jo Knight and Michael Owen and Sagar Parikh and John Strauss and Abram Sterne and Federica Tozzi and Julia Perry and Pierandrea Muglia and John Vincent and Peter McGuffin and Anne Farmer",

year = "2010",

month = oct,

doi = "10.1002/ajmg.b.31101",

language = "English",

volume = "153B",

pages = "1298 -- 1304",

journal = "American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics",

issn = "1552-485X",

publisher = "Wiley-Liss Inc.",

number = "7",

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Cohen-Woods, S , Craig, I , Gaysina, D , Gray, J , Gunasinghe, C, Craddock, N, Elkin, A, Jones, L, Kennedy, J, King, N, Korszun, A, Knight, J, Owen, M, Parikh, S, Strauss, J, Sterne, A, Tozzi, F, Perry, J, Muglia, P, Vincent, J, McGuffin, P & Farmer, A 2010, 'The Bipolar Association Case-Control Study (BACCS) and meta-analysis: No association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, vol. 153B, no. 7, pp. 1298 - 1304. https://doi.org/10.1002/ajmg.b.31101

The Bipolar Association Case-Control Study (BACCS) and meta-analysis: No association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder. / Cohen-Woods, Sarah ; Craig, Ian ; Gaysina, Darya et al.
In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, Vol. 153B, No. 7, 10.2010, p. 1298 - 1304.

Research output: Contribution to journal › Article › peer-review

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T1 - The Bipolar Association Case-Control Study (BACCS) and meta-analysis

T2 - No association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder

AU - Cohen-Woods, Sarah

AU - Craig, Ian

AU - Gaysina, Darya

AU - Gray, Joanna

AU - Gunasinghe, Cerisse

AU - Craddock, Nick

AU - Elkin, Amanda

AU - Jones, Lisa

AU - Kennedy, James

AU - King, Nicole

AU - Korszun, Ania

AU - Knight, Jo

AU - Owen, Michael

AU - Parikh, Sagar

AU - Strauss, John

AU - Sterne, Abram

AU - Tozzi, Federica

AU - Perry, Julia

AU - Muglia, Pierandrea

AU - Vincent, John

AU - McGuffin, Peter

AU - Farmer, Anne

PY - 2010/10

Y1 - 2010/10

N2 - Bipolar disorder (BD) is a complex genetic disease for which the underlying pathophysiology has yet to be fully explained. 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. A single base variant in MTHFR gene (C677T) results in the production of a mildly dysfunctional thermolabile enzyme and has recently been implicated in BD. We conducted an association study of this polymorphism in 897 patients with bipolar I or bipolar II disorder, and 1,687 healthy control subjects. We found no evidence for genotypic or allelic association in this sample. We also performed a meta-analysis of our own, and all published data, and report no evidence for association. Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD.

AB - Bipolar disorder (BD) is a complex genetic disease for which the underlying pathophysiology has yet to be fully explained. 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. A single base variant in MTHFR gene (C677T) results in the production of a mildly dysfunctional thermolabile enzyme and has recently been implicated in BD. We conducted an association study of this polymorphism in 897 patients with bipolar I or bipolar II disorder, and 1,687 healthy control subjects. We found no evidence for genotypic or allelic association in this sample. We also performed a meta-analysis of our own, and all published data, and report no evidence for association. Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD.

KW - Alleles

KW - Bipolar Disorder/epidemiology

KW - Case-Control Studies

KW - Genetic Association Studies/methods

KW - Genotype

KW - Humans

KW - Methylenetetrahydrofolate Reductase (NADPH2)/genetics

KW - Polymorphism, Single Nucleotide

U2 - 10.1002/ajmg.b.31101

DO - 10.1002/ajmg.b.31101

M3 - Article

C2 - 20552676

SN - 1552-485X

VL - 153B

SP - 1298

EP - 1304

JO - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

IS - 7

ER -

The Bipolar Association Case-Control Study (BACCS) and meta-analysis: No association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder

Abstract

Keywords

UN SDGs

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