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The clinical significance and prognostic value of right ventricular wall tension in moderate or severe tricuspid regurgitation

Research output: Contribution to journalArticlepeer-review

Sahrai Saeed, Karine Grigoryan, Jenna Smith, Harminder Gill, Dario Freitas, Øyvind Bleie, John B. Chambers, Ronak Rajani

Original languageEnglish
Pages (from-to)1371-1379
Number of pages9
JournalFuture Cardiology
Issue number8
PublishedNov 2021

Bibliographical note

Publisher Copyright: © 2021 Future Medicine Ltd.

King's Authors


Background: We aim to explore the determinants of right ventricular wall tension (RV base-to-apex length multiplied by systolic pulmonary artery pressure [RV WT] and association with all-cause mortality in patients with moderate-to-severe tricuspid regurgitation. Materials & methods: Of total, 180 patients (71 ± 15 years, 54% females) were included. An increased RV WT was defined as >3300 mmHg x mm. Results: Patients with increased RV WT (n = 85, 47%) were more likely to be male and taller than patients with normal RV WT. In a multivariable-adjusted model, increased RV WT was associated with a 2.6-fold higher risk of all-cause mortality (HR: 2.59, 95% CI: 1.65-4.06). Conclusion: In patients with significant tricuspid regurgitation, an increased RV WT was common, and associated with a 2.6-fold higher risk of all-cause mortality. Male sex was the only independent determinant.

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