The Cloning and Expression of Human Monoclonal Antibodies: Implications for Allergen Immunotherapy

Louisa James

doi:10.1007/s11882-015-0588-z

The Cloning and Expression of Human Monoclonal Antibodies: Implications for Allergen Immunotherapy

Louisa James^*

^*Corresponding author for this work

Randall Centre of Cell & Molecular Biophysics

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

205 Downloads (Pure)

Abstract

Allergic responses are dependent on the highly specific effector functions of IgE antibodies. Conversely, antibodies that block the activity of IgE can mediate tolerance to allergen. Technologies that harness the unparalleled specificity of antibody responses have revolutionized the way that we diagnose and treat human disease. This area of research continues to advance at a rapid pace and has had a significant impact on our understanding of allergic disease. This review will present an overview of humoral responses and provide an up-to-date summary of technologies used in the generation of human monoclonal antibodies. The impact that monoclonal antibodies have on allergic disease will be discussed, with a particular focus on allergen immunotherapy, which remains the only form of treatment that can modulate the underlying immune mechanisms and induce long-term clinical tolerance.

Original language	English
Article number	15
Pages (from-to)	1-9
Number of pages	9
Journal	CURRENT ALLERGY AND ASTHMA REPORTS
Volume	16
Issue number	2
DOIs	https://doi.org/10.1007/s11882-015-0588-z
Publication status	Published - 1 Jan 2016

Keywords

Allergen immunotherapy
Allergy
B cells
Cloning
Human
Human monoclonal antibodies

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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art_3A10.1007_2Fs11882_015_0588_zFinal published version, 1.64 MBLicence: CC BY

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The Cloning and Expression of Human Monoclonal Antibodies: Implications for Allergen Immunotherapy

Abstract

Keywords

UN SDGs

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