The Consortium on Vulnerability to Externalizing Disorders and Addictions (c-VEDA): an accelerated longitudinal cohort of children and adolescents in India

Yuning Zhang; Nilakshi Vaidya; Udita Iyengar; Eesha Sharma; Bharath Holla; Chirag K. Ahuja; Gareth J. Barker; Debasish Basu; Rose Dawn Bharath; Amit Chakrabarti; Sylvane Desrivieres; Paul Elliott; Gwen Fernandes; Amritha Gourisankar; Jon Heron; Matthew Hickman; Preeti Jacob; Sanjeev Jain; Deepak Jayarajan; Kartik Kalyanram; Kamakshi Kartik; Murali Krishna; Ghattu Krishnaveni; Keshav Kumar; Kalyanaraman Kumaran; Rebecca Kuriyan; Pratima Murthy; Dimitri P. Orfanos; Meera Purushottam; Madhavi Rangaswamy; Sunita Simon Kupard; Lenin Singh; Roshan Singh; B. N. Subodh; Kandavel Thennarasu; Mireille Toledano; Mathew Varghese; Vivek Benegal; Gunter Schumann

doi:10.1038/s41380-020-0656-1

The Consortium on Vulnerability to Externalizing Disorders and Addictions (c-VEDA): an accelerated longitudinal cohort of children and adolescents in India

Yuning Zhang, Nilakshi Vaidya, Udita Iyengar, Eesha Sharma, Bharath Holla, Chirag K. Ahuja, Gareth J. Barker, Debasish Basu, Rose Dawn Bharath, Amit Chakrabarti, Sylvane Desrivieres, Paul Elliott, Gwen Fernandes, Amritha Gourisankar, Jon Heron, Matthew Hickman, Preeti Jacob, Sanjeev Jain, Deepak Jayarajan, Kartik KalyanramKamakshi Kartik, Murali Krishna, Ghattu Krishnaveni, Keshav Kumar, Kalyanaraman Kumaran, Rebecca Kuriyan, Pratima Murthy, Dimitri P. Orfanos, Meera Purushottam, Madhavi Rangaswamy, Sunita Simon Kupard, Lenin Singh, Roshan Singh, B. N. Subodh, Kandavel Thennarasu, Mireille Toledano, Mathew Varghese, Vivek Benegal, Gunter Schumann

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The global burden of disease attributable to externalizing disorders such as alcohol misuse calls urgently for effective prevention and intervention. As our current knowledge is mainly derived from high-income countries such in Europe and North-America, it is difficult to address the wider socio-cultural, psychosocial context, and genetic factors in which risk and resilience are embedded in low- and medium-income countries. c-VEDA was established as the first and largest India-based multi-site cohort investigating the vulnerabilities for the development of externalizing disorders, addictions, and other mental health problems. Using a harmonised data collection plan coordinated with multiple cohorts in China, USA, and Europe, baseline data were collected from seven study sites between November 2016 and May 2019. Nine thousand and ten participants between the ages of 6 and 23 were assessed during this time, amongst which 1278 participants underwent more intensive assessments including MRI scans. Both waves of follow-ups have started according to the accelerated cohort structure with planned missingness design. Here, we present descriptive statistics on several key domains of assessments, and the full baseline dataset will be made accessible for researchers outside the consortium in September 2019. More details can be found on our website [cveda.org].

Original language	English
Pages (from-to)	1618-1630
Number of pages	13
Journal	Molecular Psychiatry
Volume	25
Issue number	8
DOIs	https://doi.org/10.1038/s41380-020-0656-1
Publication status	Published - 1 Aug 2020

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http://www.nature.com/articles/s41380-020-0656-1

Cite this

Zhang, Y., Vaidya, N., Iyengar, U., Sharma, E., Holla, B., Ahuja, C. K., Barker, G. J., Basu, D., Bharath, R. D., Chakrabarti, A., Desrivieres, S., Elliott, P., Fernandes, G., Gourisankar, A., Heron, J., Hickman, M., Jacob, P., Jain, S., Jayarajan, D., ... Schumann, G. (2020). The Consortium on Vulnerability to Externalizing Disorders and Addictions (c-VEDA): an accelerated longitudinal cohort of children and adolescents in India. Molecular Psychiatry, 25(8), 1618-1630. https://doi.org/10.1038/s41380-020-0656-1

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title = "The Consortium on Vulnerability to Externalizing Disorders and Addictions (c-VEDA): an accelerated longitudinal cohort of children and adolescents in India",

abstract = "The global burden of disease attributable to externalizing disorders such as alcohol misuse calls urgently for effective prevention and intervention. As our current knowledge is mainly derived from high-income countries such in Europe and North-America, it is difficult to address the wider socio-cultural, psychosocial context, and genetic factors in which risk and resilience are embedded in low- and medium-income countries. c-VEDA was established as the first and largest India-based multi-site cohort investigating the vulnerabilities for the development of externalizing disorders, addictions, and other mental health problems. Using a harmonised data collection plan coordinated with multiple cohorts in China, USA, and Europe, baseline data were collected from seven study sites between November 2016 and May 2019. Nine thousand and ten participants between the ages of 6 and 23 were assessed during this time, amongst which 1278 participants underwent more intensive assessments including MRI scans. Both waves of follow-ups have started according to the accelerated cohort structure with planned missingness design. Here, we present descriptive statistics on several key domains of assessments, and the full baseline dataset will be made accessible for researchers outside the consortium in September 2019. More details can be found on our website [cveda.org].",

author = "Yuning Zhang and Nilakshi Vaidya and Udita Iyengar and Eesha Sharma and Bharath Holla and Ahuja, {Chirag K.} and Barker, {Gareth J.} and Debasish Basu and Bharath, {Rose Dawn} and Amit Chakrabarti and Sylvane Desrivieres and Paul Elliott and Gwen Fernandes and Amritha Gourisankar and Jon Heron and Matthew Hickman and Preeti Jacob and Sanjeev Jain and Deepak Jayarajan and Kartik Kalyanram and Kamakshi Kartik and Murali Krishna and Ghattu Krishnaveni and Keshav Kumar and Kalyanaraman Kumaran and Rebecca Kuriyan and Pratima Murthy and Orfanos, {Dimitri P.} and Meera Purushottam and Madhavi Rangaswamy and Kupard, {Sunita Simon} and Lenin Singh and Roshan Singh and Subodh, {B. N.} and Kandavel Thennarasu and Mireille Toledano and Mathew Varghese and Vivek Benegal and Gunter Schumann",

year = "2020",

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doi = "10.1038/s41380-020-0656-1",

language = "English",

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pages = "1618--1630",

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Zhang, Y, Vaidya, N, Iyengar, U, Sharma, E, Holla, B, Ahuja, CK, Barker, GJ, Basu, D, Bharath, RD, Chakrabarti, A, Desrivieres, S, Elliott, P, Fernandes, G, Gourisankar, A, Heron, J, Hickman, M, Jacob, P, Jain, S, Jayarajan, D, Kalyanram, K, Kartik, K, Krishna, M, Krishnaveni, G, Kumar, K, Kumaran, K, Kuriyan, R, Murthy, P, Orfanos, DP, Purushottam, M, Rangaswamy, M, Kupard, SS, Singh, L, Singh, R, Subodh, BN, Thennarasu, K, Toledano, M, Varghese, M, Benegal, V & Schumann, G 2020, 'The Consortium on Vulnerability to Externalizing Disorders and Addictions (c-VEDA): an accelerated longitudinal cohort of children and adolescents in India', Molecular Psychiatry, vol. 25, no. 8, pp. 1618-1630. https://doi.org/10.1038/s41380-020-0656-1

TY - JOUR

T1 - The Consortium on Vulnerability to Externalizing Disorders and Addictions (c-VEDA): an accelerated longitudinal cohort of children and adolescents in India

AU - Zhang, Yuning

AU - Vaidya, Nilakshi

AU - Iyengar, Udita

AU - Sharma, Eesha

AU - Holla, Bharath

AU - Ahuja, Chirag K.

AU - Barker, Gareth J.

AU - Basu, Debasish

AU - Bharath, Rose Dawn

AU - Chakrabarti, Amit

AU - Desrivieres, Sylvane

AU - Elliott, Paul

AU - Fernandes, Gwen

AU - Gourisankar, Amritha

AU - Heron, Jon

AU - Hickman, Matthew

AU - Jacob, Preeti

AU - Jain, Sanjeev

AU - Jayarajan, Deepak

AU - Kalyanram, Kartik

AU - Kartik, Kamakshi

AU - Krishna, Murali

AU - Krishnaveni, Ghattu

AU - Kumar, Keshav

AU - Kumaran, Kalyanaraman

AU - Kuriyan, Rebecca

AU - Murthy, Pratima

AU - Orfanos, Dimitri P.

AU - Purushottam, Meera

AU - Rangaswamy, Madhavi

AU - Kupard, Sunita Simon

AU - Singh, Lenin

AU - Singh, Roshan

AU - Subodh, B. N.

AU - Thennarasu, Kandavel

AU - Toledano, Mireille

AU - Varghese, Mathew

AU - Benegal, Vivek

AU - Schumann, Gunter

PY - 2020/8/1

Y1 - 2020/8/1

N2 - The global burden of disease attributable to externalizing disorders such as alcohol misuse calls urgently for effective prevention and intervention. As our current knowledge is mainly derived from high-income countries such in Europe and North-America, it is difficult to address the wider socio-cultural, psychosocial context, and genetic factors in which risk and resilience are embedded in low- and medium-income countries. c-VEDA was established as the first and largest India-based multi-site cohort investigating the vulnerabilities for the development of externalizing disorders, addictions, and other mental health problems. Using a harmonised data collection plan coordinated with multiple cohorts in China, USA, and Europe, baseline data were collected from seven study sites between November 2016 and May 2019. Nine thousand and ten participants between the ages of 6 and 23 were assessed during this time, amongst which 1278 participants underwent more intensive assessments including MRI scans. Both waves of follow-ups have started according to the accelerated cohort structure with planned missingness design. Here, we present descriptive statistics on several key domains of assessments, and the full baseline dataset will be made accessible for researchers outside the consortium in September 2019. More details can be found on our website [cveda.org].

AB - The global burden of disease attributable to externalizing disorders such as alcohol misuse calls urgently for effective prevention and intervention. As our current knowledge is mainly derived from high-income countries such in Europe and North-America, it is difficult to address the wider socio-cultural, psychosocial context, and genetic factors in which risk and resilience are embedded in low- and medium-income countries. c-VEDA was established as the first and largest India-based multi-site cohort investigating the vulnerabilities for the development of externalizing disorders, addictions, and other mental health problems. Using a harmonised data collection plan coordinated with multiple cohorts in China, USA, and Europe, baseline data were collected from seven study sites between November 2016 and May 2019. Nine thousand and ten participants between the ages of 6 and 23 were assessed during this time, amongst which 1278 participants underwent more intensive assessments including MRI scans. Both waves of follow-ups have started according to the accelerated cohort structure with planned missingness design. Here, we present descriptive statistics on several key domains of assessments, and the full baseline dataset will be made accessible for researchers outside the consortium in September 2019. More details can be found on our website [cveda.org].

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U2 - 10.1038/s41380-020-0656-1

DO - 10.1038/s41380-020-0656-1

M3 - Article

SN - 1359-4184

VL - 25

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EP - 1630

JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 8

ER -

The Consortium on Vulnerability to Externalizing Disorders and Addictions (c-VEDA): an accelerated longitudinal cohort of children and adolescents in India

Abstract

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