The Developing Human Connectome Project: a Minimal Processing Pipeline for Neonatal Cortical Surface Reconstruction

Antonios Makropoulos, Emma C. Robinson, Andreas Schuh, Robert Wright, Sean Fitzgibbon, Jelena Bozek, Serena J. Counsell, Johannes Steinweg, Katy Vecchiato, Jonathan Passerat-Palmbach, Gregor Lenz, Filippo Mortari, Tencho Tenev, Eugene P. Duff, Matteo Bastiani, Lucilio Cordero Grande, Emer J. Hughes, Nora Tusor, Jacques-Donald Tournier, Jana HutterAnthony N. Price, Rui Pedro A. G. Teixeira, Maria Murgasova, Suresh Victor, Christopher John Kelly, Mary A. Rutherford, Stephen M. Smith, A. David Edwards, Joseph V. Hajnal, Mark Jenkinson, Daniel Rueckert

Research output: Contribution to journalArticlepeer-review

227 Citations (Scopus)
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Abstract

The Developing Human Connectome Project (dHCP) seeks to create the first 4-dimensional connectome of early life. Understanding this connectome in detail may provide insights into normal as well as abnormal patterns of brain development.
Following established best practices adopted by the WU-MINN Human Connectome Project (HCP), and pioneered by FreeSurfer, the project utilises cortical surface-based processing pipelines. In this paper, we propose a fully automated processing pipeline for the structural Magnetic Resonance Imaging (MRI) of the developing neonatal brain. This proposed pipeline consists of a refined framework for cortical and sub-cortical volume segmentation, cortical surface extraction, and cortical surface inflation, which has been specifically designed to address considerable differences between adult and neonatal brains, as imaged using MRI. Using the proposed pipeline our results demonstrate that images collected from 465 subjects ranging from 28 to 45 weeks post-menstrual age (PMA) can be processed fully automatically; generating cortical surface models that are topologically correct, and correspond well with manual evaluations of tissue boundaries in 85\% of cases. Results improve on state-of-the-art neonatal tissue segmentation models and significant errors were found in only 2\% of cases, where these corresponded to subjects with high motion. Downstream, these surfaces will enhance comparisons of functional and diffusion MRI datasets, supporting the modelling of emerging patterns of brain connectivity.
Original languageEnglish
Pages (from-to)88-112
JournalNeuroImage
Volume173
Early online date31 Jan 2018
DOIs
Publication statusPublished - Jun 2018

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