The development and validation of the King's Sarcoidosis Questionnaire for the assessment of health status

Amit Patel; Richard J. Siegert; Daniel Creamer; Genevieve Larkin; Toby M. Maher; Elisabetta A. Renzoni; Athol U. Wells; Irene J. Higginson; Surinder Birring

doi:10.1136/thoraxjnl-2012-201962

The development and validation of the King's Sarcoidosis Questionnaire for the assessment of health status

Amit Patel, Richard J. Siegert, Daniel Creamer, Genevieve Larkin, Toby M. Maher, Elisabetta A. Renzoni, Athol U. Wells, Irene J. Higginson, Surinder Birring

Cicely Saunders Institute of Palliative Care, Policy & Rehabilitation

Research output: Contribution to journal › Article › peer-review

90 Citations (Scopus)

Abstract

Rationale Health status is impaired in patients with sarcoidosis. There is a paucity of tools that assess health status in sarcoidosis. The objective of this study was to develop and validate the King's Sarcoidosis Questionnaire (KSQ), a new modular health status measure.

Methods Patients with sarcoidosis were recruited from outpatient clinics. The development of the questionnaire consisted of three phases: item generation; item reduction, Rasch analysis to create unidimensional scales and validation; repeatability testing.

Results 207 patients with sarcoidosis (organ involvement: 184 lung, 54 skin, 45 eye disease) completed a 65-item preliminary questionnaire. 36 items were removed due to redundancy or poor fit to the Rasch model. The final version of the KSQ consisted of five modules (General health status, Lung, Skin, Eye, Medications). Internal consistency assessed with Cronbach's alpha coefficient was 0.70-0.93 for KSQ modules. Concurrent validity of the Lung module was high compared with St George's Respiratory Questionnaire (r=-0.83) and moderate when compared to forced vital capacity (r=0.49). Concurrent validity with skin-specific and eye-specific measures ranged from r= -0.4 to 0.8. The KSQ was repeatable over 2 weeks (n=39), intraclass correlation coefficients for modules were 0.90-0.96.

Conclusions The KSQ is a brief, valid, self-completed health status measure for sarcoidosis. It can be used in the clinic to assess sarcoidosis from the patients' perspective.

Original language	English
Pages (from-to)	57-65
Number of pages	9
Journal	Thorax
Volume	68
Issue number	1
DOIs	https://doi.org/10.1136/thoraxjnl-2012-201962
Publication status	Published - 1 Jan 2013

Keywords

Adult
Age Distribution
Ambulatory Care Facilities
Cohort Studies
Disease Progression
Eye Diseases
Female
Great Britain
Health Status
Humans
Incidence
Male
Middle Aged
Quality of Life
Questionnaires
Reproducibility of Results
Respiratory Function Tests
Risk Assessment
Sarcoidosis
Sarcoidosis, Pulmonary
Severity of Illness Index
Sex Distribution
Skin Diseases
Survival Rate

Access to Document

10.1136/thoraxjnl-2012-201962

Cite this

@article{67d832d532fc4859960bb69e79b684a1,

title = "The development and validation of the King's Sarcoidosis Questionnaire for the assessment of health status",

abstract = "Rationale Health status is impaired in patients with sarcoidosis. There is a paucity of tools that assess health status in sarcoidosis. The objective of this study was to develop and validate the King's Sarcoidosis Questionnaire (KSQ), a new modular health status measure.Methods Patients with sarcoidosis were recruited from outpatient clinics. The development of the questionnaire consisted of three phases: item generation; item reduction, Rasch analysis to create unidimensional scales and validation; repeatability testing.Results 207 patients with sarcoidosis (organ involvement: 184 lung, 54 skin, 45 eye disease) completed a 65-item preliminary questionnaire. 36 items were removed due to redundancy or poor fit to the Rasch model. The final version of the KSQ consisted of five modules (General health status, Lung, Skin, Eye, Medications). Internal consistency assessed with Cronbach's alpha coefficient was 0.70-0.93 for KSQ modules. Concurrent validity of the Lung module was high compared with St George's Respiratory Questionnaire (r=-0.83) and moderate when compared to forced vital capacity (r=0.49). Concurrent validity with skin-specific and eye-specific measures ranged from r= -0.4 to 0.8. The KSQ was repeatable over 2 weeks (n=39), intraclass correlation coefficients for modules were 0.90-0.96.Conclusions The KSQ is a brief, valid, self-completed health status measure for sarcoidosis. It can be used in the clinic to assess sarcoidosis from the patients' perspective.",

keywords = "Adult, Age Distribution, Ambulatory Care Facilities, Cohort Studies, Disease Progression, Eye Diseases, Female, Great Britain, Health Status, Humans, Incidence, Male, Middle Aged, Quality of Life, Questionnaires, Reproducibility of Results, Respiratory Function Tests, Risk Assessment, Sarcoidosis, Sarcoidosis, Pulmonary, Severity of Illness Index, Sex Distribution, Skin Diseases, Survival Rate",

author = "Amit Patel and Siegert, {Richard J.} and Daniel Creamer and Genevieve Larkin and Maher, {Toby M.} and Renzoni, {Elisabetta A.} and Wells, {Athol U.} and Higginson, {Irene J.} and Surinder Birring",

note = "This article is not freely accessible but you may have access through your institution",

year = "2013",

month = jan,

day = "1",

doi = "10.1136/thoraxjnl-2012-201962",

language = "English",

volume = "68",

pages = "57--65",

journal = "Thorax",

issn = "0040-6376",

publisher = "BRITISH MED JOURNAL PUBL GROUP",

number = "1",

}

TY - JOUR

T1 - The development and validation of the King's Sarcoidosis Questionnaire for the assessment of health status

AU - Patel, Amit

AU - Siegert, Richard J.

AU - Creamer, Daniel

AU - Larkin, Genevieve

AU - Maher, Toby M.

AU - Renzoni, Elisabetta A.

AU - Wells, Athol U.

AU - Higginson, Irene J.

AU - Birring, Surinder

N1 - This article is not freely accessible but you may have access through your institution

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Rationale Health status is impaired in patients with sarcoidosis. There is a paucity of tools that assess health status in sarcoidosis. The objective of this study was to develop and validate the King's Sarcoidosis Questionnaire (KSQ), a new modular health status measure.Methods Patients with sarcoidosis were recruited from outpatient clinics. The development of the questionnaire consisted of three phases: item generation; item reduction, Rasch analysis to create unidimensional scales and validation; repeatability testing.Results 207 patients with sarcoidosis (organ involvement: 184 lung, 54 skin, 45 eye disease) completed a 65-item preliminary questionnaire. 36 items were removed due to redundancy or poor fit to the Rasch model. The final version of the KSQ consisted of five modules (General health status, Lung, Skin, Eye, Medications). Internal consistency assessed with Cronbach's alpha coefficient was 0.70-0.93 for KSQ modules. Concurrent validity of the Lung module was high compared with St George's Respiratory Questionnaire (r=-0.83) and moderate when compared to forced vital capacity (r=0.49). Concurrent validity with skin-specific and eye-specific measures ranged from r= -0.4 to 0.8. The KSQ was repeatable over 2 weeks (n=39), intraclass correlation coefficients for modules were 0.90-0.96.Conclusions The KSQ is a brief, valid, self-completed health status measure for sarcoidosis. It can be used in the clinic to assess sarcoidosis from the patients' perspective.

AB - Rationale Health status is impaired in patients with sarcoidosis. There is a paucity of tools that assess health status in sarcoidosis. The objective of this study was to develop and validate the King's Sarcoidosis Questionnaire (KSQ), a new modular health status measure.Methods Patients with sarcoidosis were recruited from outpatient clinics. The development of the questionnaire consisted of three phases: item generation; item reduction, Rasch analysis to create unidimensional scales and validation; repeatability testing.Results 207 patients with sarcoidosis (organ involvement: 184 lung, 54 skin, 45 eye disease) completed a 65-item preliminary questionnaire. 36 items were removed due to redundancy or poor fit to the Rasch model. The final version of the KSQ consisted of five modules (General health status, Lung, Skin, Eye, Medications). Internal consistency assessed with Cronbach's alpha coefficient was 0.70-0.93 for KSQ modules. Concurrent validity of the Lung module was high compared with St George's Respiratory Questionnaire (r=-0.83) and moderate when compared to forced vital capacity (r=0.49). Concurrent validity with skin-specific and eye-specific measures ranged from r= -0.4 to 0.8. The KSQ was repeatable over 2 weeks (n=39), intraclass correlation coefficients for modules were 0.90-0.96.Conclusions The KSQ is a brief, valid, self-completed health status measure for sarcoidosis. It can be used in the clinic to assess sarcoidosis from the patients' perspective.

KW - Adult

KW - Age Distribution

KW - Ambulatory Care Facilities

KW - Cohort Studies

KW - Disease Progression

KW - Eye Diseases

KW - Female

KW - Great Britain

KW - Health Status

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Quality of Life

KW - Questionnaires

KW - Reproducibility of Results

KW - Respiratory Function Tests

KW - Risk Assessment

KW - Sarcoidosis

KW - Sarcoidosis, Pulmonary

KW - Severity of Illness Index

KW - Sex Distribution

KW - Skin Diseases

KW - Survival Rate

U2 - 10.1136/thoraxjnl-2012-201962

DO - 10.1136/thoraxjnl-2012-201962

M3 - Article

C2 - 23065052

SN - 0040-6376

VL - 68

SP - 57

EP - 65

JO - Thorax

JF - Thorax

IS - 1

ER -

The development and validation of the King's Sarcoidosis Questionnaire for the assessment of health status

Abstract

Keywords

Access to Document

Fingerprint

Cite this