TY - JOUR
T1 - The development of cognitive control in children with autism spectrum disorder or obsessive-compulsive disorder
T2 - A longitudinal fMRI study
AU - The TACTICS consortium
AU - Gooskens, Bram
AU - Bos, Dienke J.
AU - Naaijen, Jilly
AU - Akkermans, Sophie E.A.
AU - Kaiser, Anna
AU - Hohmann, Sarah
AU - Bruchhage, Muriel M.K.
AU - Banaschewski, Tobias
AU - Brandeis, Daniel
AU - Williams, Steven C.R.
AU - Lythgoe, David J.
AU - Buitelaar, Jan K.
AU - Oranje, Bob
AU - Durston, Sarah
N1 - Publisher Copyright:
© 2021 The Authors
PY - 2021/6
Y1 - 2021/6
N2 - Repetitive behavior is a core symptom of Autism Spectrum Disorder (ASD) and Obsessive-Compulsive Disorder (OCD), and has been associated with impairments in cognitive control. However, it is unclear how cognitive control and associated neural circuitry relate to the development of repetitive behavior in children with these disorders. In a multicenter, longitudinal study (TACTICS; Translational Adolescent and Childhood Therapeutic Interventions in Compulsive Syndromes), the development of cognitive control was assessed during late childhood using a longitudinal fMRI design with a modified stop-signal task in children with ASD or OCD, and typically developing (TD) children (baseline: N = 95 (8-12 y), follow-up: N = 53 (10-14 y), average interval: 1.48 y (sd: 0.36, range: 0.98–2.52 y). Stop-signal reaction time (SSRT) decreased over development, regardless of diagnosis. Repetitive behavior in children with ASD and OCD was not associated with performance on the stop-signal task. There were no whole-brain between-group differences in brain activity, but ROI-analyses showed increases in activity in right precentral gyrus over development for children with OCD. In sum, even though subtle differences were observed in the development of brain activity in children with OCD, overall the findings suggest that the development of cognitive control, as assessed by the stop signal task, is similar to typical in children with ASD and OCD.
AB - Repetitive behavior is a core symptom of Autism Spectrum Disorder (ASD) and Obsessive-Compulsive Disorder (OCD), and has been associated with impairments in cognitive control. However, it is unclear how cognitive control and associated neural circuitry relate to the development of repetitive behavior in children with these disorders. In a multicenter, longitudinal study (TACTICS; Translational Adolescent and Childhood Therapeutic Interventions in Compulsive Syndromes), the development of cognitive control was assessed during late childhood using a longitudinal fMRI design with a modified stop-signal task in children with ASD or OCD, and typically developing (TD) children (baseline: N = 95 (8-12 y), follow-up: N = 53 (10-14 y), average interval: 1.48 y (sd: 0.36, range: 0.98–2.52 y). Stop-signal reaction time (SSRT) decreased over development, regardless of diagnosis. Repetitive behavior in children with ASD and OCD was not associated with performance on the stop-signal task. There were no whole-brain between-group differences in brain activity, but ROI-analyses showed increases in activity in right precentral gyrus over development for children with OCD. In sum, even though subtle differences were observed in the development of brain activity in children with OCD, overall the findings suggest that the development of cognitive control, as assessed by the stop signal task, is similar to typical in children with ASD and OCD.
KW - Autism spectrum disorder
KW - Cognitive control
KW - fMRI
KW - Obsessive-compulsive disorder
KW - Repetitive behavior
UR - http://www.scopus.com/inward/record.url?scp=85149603682&partnerID=8YFLogxK
U2 - 10.1016/j.ynirp.2021.100015
DO - 10.1016/j.ynirp.2021.100015
M3 - Article
AN - SCOPUS:85149603682
SN - 2666-9560
VL - 1
JO - Neuroimage: Reports
JF - Neuroimage: Reports
IS - 2
M1 - 100015
ER -