The Diverse Ethics of Translational Research

Neema Sofaer; Nir Eyal

doi:10.1080/15265161.2010.494214

The Diverse Ethics of Translational Research

Neema Sofaer
, Nir Eyal

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Commentators on the ethics of translational research find it morally problematic. Types of translational research are said to involve questionable benefits, special risks, additional barriers to informed consent, and severe conflicts of interest. Translational research conducted on the global poor is thought to exploit them and increase international disparities. Some commentators support especially stringent ethical review. However, such concerns are grounded only in pre-approval translational research (now called T1). Whether or not T1 has these features, translational research beyond approval (T2: phase IV, health services, and implementation research) is unlikely to and, when conducted on the global poor, may support development. Therefore, insofar as T1 is morally problematic, and no independent objections to T2 exist, the ethics of translational research is diverse: while some translational research is problematic, some is not. Funding and oversight should reflect this diversity, and T2 should be encouraged, particularly when conducted among the global poor.

Original language	English
Pages (from-to)	19 - 30
Number of pages	12
Journal	AMERICAN JOURNAL OF BIOETHICS
Volume	10
Issue number	8
DOIs	https://doi.org/10.1080/15265161.2010.494214
Publication status	Published - 2010

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10.1080/15265161.2010.494214

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title = "The Diverse Ethics of Translational Research",

abstract = "Commentators on the ethics of translational research find it morally problematic. Types of translational research are said to involve questionable benefits, special risks, additional barriers to informed consent, and severe conflicts of interest. Translational research conducted on the global poor is thought to exploit them and increase international disparities. Some commentators support especially stringent ethical review. However, such concerns are grounded only in pre-approval translational research (now called T1). Whether or not T1 has these features, translational research beyond approval (T2: phase IV, health services, and implementation research) is unlikely to and, when conducted on the global poor, may support development. Therefore, insofar as T1 is morally problematic, and no independent objections to T2 exist, the ethics of translational research is diverse: while some translational research is problematic, some is not. Funding and oversight should reflect this diversity, and T2 should be encouraged, particularly when conducted among the global poor.",

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The Diverse Ethics of Translational Research

Abstract

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