The dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sample

TY - JOUR

T1 - The dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sample

AU - Chen, C K

AU - Chen, S L

AU - Mill, J

AU - Huang, Y S

AU - Lin, S K

AU - Curran, S

AU - Purcell, S

AU - Sham, P

AU - Asherson, P

PY - 2003

Y1 - 2003

N2 - Genetic variation of the dopamine transporter gene (DAT1) is of particular interest in the study of attention-deficit hyperactivity disorder (ADHID), since stimulant drugs interact directly with the transporter protein. Association between ADHD and the 10-repeat allele of a 40-bp VNTR polymorphism that lies within the T'-UTR of DAT1 was first reported in 1995, a finding that has been replicated in at least six independent samples from Caucasian populations. We analysed the DAT1 polymorphism in a sample of 110 Taiwanese probands with a DSM-IV diagnosis of ADHD and found evidence of increased transmission of the 10-repeat allele using TRANSMIT (chi(2) = 10.8, 1 d.f., p= 0.001, 013=2.9, 95% CI 1.4-6.3). These data give rise to a similar odds ratio to that observed in Caucasian poplulations despite a far higher frequency of the risk allele in this Taiwanese population; 82.3% in the un-transmitted parental alleles and 94.5% in the ADHD probands. These data support the role of DAT1 in ADHD susceptibility among Asian populations.

AB - Genetic variation of the dopamine transporter gene (DAT1) is of particular interest in the study of attention-deficit hyperactivity disorder (ADHID), since stimulant drugs interact directly with the transporter protein. Association between ADHD and the 10-repeat allele of a 40-bp VNTR polymorphism that lies within the T'-UTR of DAT1 was first reported in 1995, a finding that has been replicated in at least six independent samples from Caucasian populations. We analysed the DAT1 polymorphism in a sample of 110 Taiwanese probands with a DSM-IV diagnosis of ADHD and found evidence of increased transmission of the 10-repeat allele using TRANSMIT (chi(2) = 10.8, 1 d.f., p= 0.001, 013=2.9, 95% CI 1.4-6.3). These data give rise to a similar odds ratio to that observed in Caucasian poplulations despite a far higher frequency of the risk allele in this Taiwanese population; 82.3% in the un-transmitted parental alleles and 94.5% in the ADHD probands. These data support the role of DAT1 in ADHD susceptibility among Asian populations.

U2 - 10.1038/sj.mp.4001238

DO - 10.1038/sj.mp.4001238

M3 - Article

VL - 8

SP - 393

EP - 396

JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 4

ER -