The effect of age on in vitro motility speed of slow myosin extracted from single rat soleus fibres

P Hook, X Li, J Sleep, S Hughes, L Larsson

Research output: Contribution to journalConference paper

10 Citations (Scopus)

Abstract

The effect of age on the motor protein myosin was examined in a novel in vitro motility assay. Myosin was extracted from soleus fibres of young (3-6 month) and old (20-24 month) rats. All fibres expressed the type I myosin heavy chain (MyHC) and the slow isoforms of the myosin light chains (MyLCs). In vitro motility speed was significantly (P <0.001) faster in the young adult (1.43 +/- 0.23 mu m s(-1)) than in the aged group (1.27 +/- 0.23 mu m s(-1)). The result indicates that the age-related decrease in contractile speed observed in slow fibres may be the effect of a change in the properties of myosin with age.
Original languageEnglish
Pages (from-to)325 - 326
Number of pages2
JournalActa Physiologica Scandinavica
Volume167
Issue number4
Publication statusPublished - 1999
EventSymposium on The Age-Related Motor Handicap - Basic and Clinical Studies of Skeletal Muscle - STOCKHOLM, Sweden
Duration: 1 Jan 1999 → …

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