Abstract
The effect of age on the motor protein myosin was examined in a novel in vitro motility assay. Myosin was extracted from soleus fibres of young (3-6 month) and old (20-24 month) rats. All fibres expressed the type I myosin heavy chain (MyHC) and the slow isoforms of the myosin light chains (MyLCs). In vitro motility speed was significantly (P <0.001) faster in the young adult (1.43 +/- 0.23 mu m s(-1)) than in the aged group (1.27 +/- 0.23 mu m s(-1)). The result indicates that the age-related decrease in contractile speed observed in slow fibres may be the effect of a change in the properties of myosin with age.
Original language | English |
---|---|
Pages (from-to) | 325 - 326 |
Number of pages | 2 |
Journal | Acta Physiologica Scandinavica |
Volume | 167 |
Issue number | 4 |
Publication status | Published - 1999 |
Event | Symposium on The Age-Related Motor Handicap - Basic and Clinical Studies of Skeletal Muscle - STOCKHOLM, Sweden Duration: 1 Jan 1999 → … |