The effect of electrolyte on the morphology of vesicles composed of the dialkyl polyoxyethylene ether surfactant 2C(18)E(12)

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Abstract

Small-angle neutron-scattering (SANS) studies were performed on vesicles composed of 1,2-di-O-octadecyl-rac-glyceryl-3-(omega-methoxydodecaethylene glycol), in deuterium oxide (D2O) solutions with various ionic strengths of LiCl, NaCl and NaI. Gross vesicle morphologies, examined using freeze-fracture electron microscopy, showed that NaCl promoted the formation of multilamellar vesicles. Model fitting of the SANS data showed changes in bilayer parameters such as thickness and repeat spacings, in response to the presence of ions in the bulk solution. 2C(18)E(12) vesicles in D2O are shown to exist as predominantly unilamellar structures with a bilayer thickness of similar to51 Angstrom. Vesicles in increasing concentrations of LiCl and NaCl exhibit decreased layer thickness and increased lamelarity. Little change was observed for vesicles formed in NaI solutions. We suggest that these changes result from intrusion of E-12 headgroups into the alkyl chain region of the vesicle bilayers, in response to the increase in concentration of ions present and their charge density. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)27 - 36
Number of pages10
JournalChemistry and Physics of Lipids
Volume133
Issue number1
DOIs
Publication statusPublished - Jan 2005

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