TY - JOUR
T1 - The effect of ethnicity on anatomic success following macular hole surgery
T2 - a multicentre cohort study
AU - Laviers, Heidi
AU - Papavasileiou, Evangelia
AU - Bruce, Charlotte
AU - Maubon, Laura
AU - Radia, Meera
AU - Dervenis, Nikolaos
AU - Zuckerman, Benjamin
AU - Loh, Graeme K
AU - Theodorou, Olga
AU - Douiri, Abdel
AU - Zambarakji, Hadi
AU - Sandinha, Teresa
AU - Steel, David H
AU - Kirthi, Varo
AU - McKechnie, Cordelia
AU - Zakir, Rahila
AU - Duguid, Graham
AU - Jackson, Timothy L
N1 - Funding Information:
AD acknowledges funding support from the National Institute for Health Research (NIHR), Applied Research Collaboration (ARC) South London at King’s College Hospital NHS Foundation Trust, the Royal College of Physicians, and the NIHR Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2023/6
Y1 - 2023/6
N2 - Purpose: The purpose is to assess the effect of ethnicity on surgical macular hole closure. Methods: A retrospective cohort study was undertaken in five UK National Health Service Hospitals. We included all patients with known ethnicity undergoing vitrectomy, internal limiting membrane peel, and gas/oil tamponade for all stages of primary full-thickness macular hole (FTMH). The primary outcome was anatomic success, defined as FTMH closure with one operation. The secondary outcome was mean change in best-corrected visual acuity (BCVA) comparing baseline with final review. Results: Of 334 operations, the ethnicity profile comprised 78.7% White patients, 11.7% Black patients, 8.1% Asian patients, and 1.5% in mixed/other ethnicities. Mean age was 69.7 years with 68.5% females. Overall, 280 (83.8%) had anatomic success. Anatomic failure occurred in 38.5% of Black patients versus 12.6% of White patients (relative risk: 1.788; 95% CI: 1.012 to 3.159; P = 0.045). Overall, baseline logarithm of the minimum angle of resolution BCVA improved by 0.34, from 0.95 (95% CI: 0.894 to 1.008) to 0.62 (95% CI: 0.556 to 0.676). Mean BCVA improved by 0.35 in White patients, 0.37 in Black patients, 0.23 in Asian patients, and 0.38 in mixed/other ethnicity (P = 0.689). Greater FTMH minimum linear diameter was associated with an increased risk of anatomic failure (relative risk: 1.004; 95% CI: 1.002 to 1.005; P < 0.0001), whereas better pre-operative BCVA (F [1,19] = 162.90; P < 0.0001) and anatomic success (F [1,19] = 97.69; P < 0.0001) were associated with greater BCVA improvement. Socio-economic status did not significantly influence anatomic success or BCVA change. Conclusions: Black ethnicity is associated with an approximately twofold greater risk of failed FTMH surgery. The reasons for this difference warrant further study. [Figure not available: see fulltext.].
AB - Purpose: The purpose is to assess the effect of ethnicity on surgical macular hole closure. Methods: A retrospective cohort study was undertaken in five UK National Health Service Hospitals. We included all patients with known ethnicity undergoing vitrectomy, internal limiting membrane peel, and gas/oil tamponade for all stages of primary full-thickness macular hole (FTMH). The primary outcome was anatomic success, defined as FTMH closure with one operation. The secondary outcome was mean change in best-corrected visual acuity (BCVA) comparing baseline with final review. Results: Of 334 operations, the ethnicity profile comprised 78.7% White patients, 11.7% Black patients, 8.1% Asian patients, and 1.5% in mixed/other ethnicities. Mean age was 69.7 years with 68.5% females. Overall, 280 (83.8%) had anatomic success. Anatomic failure occurred in 38.5% of Black patients versus 12.6% of White patients (relative risk: 1.788; 95% CI: 1.012 to 3.159; P = 0.045). Overall, baseline logarithm of the minimum angle of resolution BCVA improved by 0.34, from 0.95 (95% CI: 0.894 to 1.008) to 0.62 (95% CI: 0.556 to 0.676). Mean BCVA improved by 0.35 in White patients, 0.37 in Black patients, 0.23 in Asian patients, and 0.38 in mixed/other ethnicity (P = 0.689). Greater FTMH minimum linear diameter was associated with an increased risk of anatomic failure (relative risk: 1.004; 95% CI: 1.002 to 1.005; P < 0.0001), whereas better pre-operative BCVA (F [1,19] = 162.90; P < 0.0001) and anatomic success (F [1,19] = 97.69; P < 0.0001) were associated with greater BCVA improvement. Socio-economic status did not significantly influence anatomic success or BCVA change. Conclusions: Black ethnicity is associated with an approximately twofold greater risk of failed FTMH surgery. The reasons for this difference warrant further study. [Figure not available: see fulltext.].
UR - https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt/gfad035/7034340?utm_source=authortollfreelink&utm_campaign=ndt&utm_medium=email&guestAccessKey=9d52fdc0-c27b-4fd8-b54d-557348d89b87
UR - http://www.scopus.com/inward/record.url?scp=85145740528&partnerID=8YFLogxK
U2 - 10.1007/s00417-022-05950-w
DO - 10.1007/s00417-022-05950-w
M3 - Article
C2 - 36602644
SN - 0721-832X
VL - 261
SP - 1535
EP - 1543
JO - Graefes Archive For Clinical and Experimental Ophthalmology
JF - Graefes Archive For Clinical and Experimental Ophthalmology
IS - 6
ER -