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The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume

Research output: Contribution to journalArticle

Michelle K. Lupton ; Lachlan Strike ; Narelle K. Hansell ; Wei Wen ; Karen A. Mather ; Nicola J. Armstrong ; Anbupalam Thalamuthu ; Katie L. McMahon ; Greig I. de Zubicaray ; Amelia A. Assareh ; Andrew Simmons ; Petroula Proitsi ; John F. Powell ; Grant W. Montgomery ; Derrek P. Hibar ; Eric Westman ; Magda Tsolaki ; Iwona Kloszewska ; Hilkka Soininen ; Patrizia Mecocci ; Bruno Velas ; Simon Lovestone ; Henry Brodaty ; David Ames ; Julian N. Trollor ; Nicholas G. Martin ; Paul M. Thompson ; Perminder S. Sachdev ; Margaret J. Wright

Original languageEnglish
Pages (from-to)68-77
Number of pages10
JournalNeurobiology of Aging
Volume40
Early online date11 Jan 2016
DOIs
StatePublished - 1 Apr 2016

Documents

  • main_NBA_final_submission (002)

    main_NBA_final_submission_002_.docx, 191 KB, application/vnd.openxmlformats-officedocument.wordprocessingml.document

    11/01/2017

    Accepted author manuscript

King's Authors

Abstract

Reduction in hippocampal and amygdala volume measured via structural magnetic resonance imaging is an early marker of Alzheimer's disease (AD). Whether genetic risk factors for AD exert an effect on these subcortical structures independent of clinical status has not been fully investigated. We examine whether increased genetic risk for AD influences hippocampal and amygdala volumes in case-control and population cohorts at different ages, in 1674 older (aged >53 years; 17% AD, 39% mild cognitive impairment [MCI]) and 467 young (16-30 years) adults. An AD polygenic risk score combining common risk variants excluding apolipoprotein E (APOE), and a single nucleotide polymorphism in TREM2, were both associated with reduced hippocampal volume in healthy older adults and those with MCI. APOE ε4 was associated with hippocampal and amygdala volume in those with AD and MCI but was not associated in healthy older adults. No associations were found in young adults. Genetic risk for AD affects the hippocampus before the clinical symptoms of AD, reflecting a neurodegenerative effect before clinical manifestations in older adults.

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