The effect of increasing physical activity and/or omega-3 supplementation on fatigue in inflammatory bowel disease

TY - JOUR

T1 - The effect of increasing physical activity and/or omega-3 supplementation on fatigue in inflammatory bowel disease

AU - McNelly, Angela S.

AU - Nathan, Indira

AU - Monti, Marilina

AU - Grimble, George K.

AU - Norton, Christine

AU - Bredin, Frances

AU - Czuber-Dochan, Wladyslawa J.

AU - Berliner, Stuart

AU - Gay, Martin A.

AU - Darvell, Marcia

AU - Terry, Helen

AU - Forbes, Alastair

PY - 2016/10/20

Y1 - 2016/10/20

N2 - This study tested the effect of individualised advice to increase physical activity and/or omega-3 fatty acid supplementation on fatigue in inactive inflammatory bowel disease (IBD). Patients in remission were recruited to a pilot study using a randomised controlled 2×2 factorial design comparing baseline and post-intervention fatigue scores. Interventions (12 weeks) were 15-minute exercise consultation and/or 2970 mg/day omega-3 supplementation and controls were general health discussion and/or placebo. From n=656 screened patients, n=74 who met the eligibility criteria were randomised, n=60 commenced and n=52 completed the study. Fatigue measured with Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) score was worse with omega-3 supplementation and unchanged with exercise advice. Fatigue, measured by Inflammatory Bowel Disease-Fatigue (IBD-F) score, was reduced with exercise advice. Advice to increase physical activity and omega-3 supplementation, singly or in combination, was shown to be well-tolerated in IBD patients in remission. There was no evidence of exercise-related adverse effects on gut symptoms. Fatigue (IBD-F score) was reduced with exercise advice, but fatigue (FACIT-F score) was unchanged. Increasing fatigue with omega-3 supplementation is unexplained. Regular exercise may be a self-management option in IBD-related fatigue.

AB - This study tested the effect of individualised advice to increase physical activity and/or omega-3 fatty acid supplementation on fatigue in inactive inflammatory bowel disease (IBD). Patients in remission were recruited to a pilot study using a randomised controlled 2×2 factorial design comparing baseline and post-intervention fatigue scores. Interventions (12 weeks) were 15-minute exercise consultation and/or 2970 mg/day omega-3 supplementation and controls were general health discussion and/or placebo. From n=656 screened patients, n=74 who met the eligibility criteria were randomised, n=60 commenced and n=52 completed the study. Fatigue measured with Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) score was worse with omega-3 supplementation and unchanged with exercise advice. Fatigue, measured by Inflammatory Bowel Disease-Fatigue (IBD-F) score, was reduced with exercise advice. Advice to increase physical activity and omega-3 supplementation, singly or in combination, was shown to be well-tolerated in IBD patients in remission. There was no evidence of exercise-related adverse effects on gut symptoms. Fatigue (IBD-F score) was reduced with exercise advice, but fatigue (FACIT-F score) was unchanged. Increasing fatigue with omega-3 supplementation is unexplained. Regular exercise may be a self-management option in IBD-related fatigue.

KW - Fatigue

KW - Inflammatory bowel disease (IBD)

KW - Nutrition

KW - Omega-3 supplementation

KW - Physical activity

UR - http://www.scopus.com/inward/record.url?scp=84994761668&partnerID=8YFLogxK

U2 - 10.12968/gasn.2016.14.8.39

DO - 10.12968/gasn.2016.14.8.39

M3 - Article

AN - SCOPUS:84994761668

SN - 1479-5248

VL - 14

SP - 39

EP - 50

JO - Gastrointestinal Nursing

JF - Gastrointestinal Nursing

IS - 8

ER -