The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life

Sean Froudist-Walsh; Michael Ap Bloomfield; Mattia Veronese; Jasmin Kroll; Vyacheslav R Karolis; Sameer Jauhar; Ilaria Bonoldi; Philip K McGuire; Shitij Kapur; Robin M Murray; Chiara Nosarti; Oliver Howes

doi:10.7554/eLife.29088

The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life

Sean Froudist-Walsh, Michael Ap Bloomfield, Mattia Veronese, Jasmin Kroll, Vyacheslav R Karolis, Sameer Jauhar, Ilaria Bonoldi, Philip K McGuire, Shitij Kapur, Robin M Murray, Chiara Nosarti, Oliver Howes

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom.
Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom.

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Abstract

Perinatal brain injuries, including hippocampal lesions, cause lasting changes in dopamine function in rodents, but it is not known if this occurs in humans. We compared adults who were born very preterm with perinatal brain injury to those born very preterm without perinatal brain injury, and age-matched controls born at full term using [18F]-DOPA PET and structural MRI. Dopamine synthesis capacity was reduced in the perinatal brain injury group relative to those without brain injury (Cohen's d = 1.36, p=0.02) and the control group (Cohen's d = 1.07, p=0.01). Hippocampal volume was reduced in the perinatal brain injury group relative to controls (Cohen's d = 1.17, p=0.01) and was positively correlated with striatal dopamine synthesis capacity (r = 0.344, p=0.03). This is the first evidence in humans linking neonatal hippocampal injury to adult dopamine dysfunction, and provides a potential mechanism linking early life risk factors to adult mental illness.

Original language	English
Journal	eLife
Volume	6
DOIs	https://doi.org/10.7554/eLife.29088
Publication status	Published - 28 Nov 2017

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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The effect of perinatal_FROUDIST-WALSH_Published28November2017_GOLD VoR (CC BY)Final published version, 479 KBLicence: CC BY

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AU - Bloomfield, Michael Ap

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AU - Karolis, Vyacheslav R

AU - Jauhar, Sameer

AU - Bonoldi, Ilaria

AU - McGuire, Philip K

AU - Kapur, Shitij

AU - Murray, Robin M

AU - Nosarti, Chiara

AU - Howes, Oliver

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AB - Perinatal brain injuries, including hippocampal lesions, cause lasting changes in dopamine function in rodents, but it is not known if this occurs in humans. We compared adults who were born very preterm with perinatal brain injury to those born very preterm without perinatal brain injury, and age-matched controls born at full term using [18F]-DOPA PET and structural MRI. Dopamine synthesis capacity was reduced in the perinatal brain injury group relative to those without brain injury (Cohen's d = 1.36, p=0.02) and the control group (Cohen's d = 1.07, p=0.01). Hippocampal volume was reduced in the perinatal brain injury group relative to controls (Cohen's d = 1.17, p=0.01) and was positively correlated with striatal dopamine synthesis capacity (r = 0.344, p=0.03). This is the first evidence in humans linking neonatal hippocampal injury to adult dopamine dysfunction, and provides a potential mechanism linking early life risk factors to adult mental illness.

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The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life

Abstract

Keywords

UN SDGs

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