The effect of preterm birth on thalamic and cortical development

Gareth Ball, James P Boardman, Daniel Rueckert, Paul Aljabar, Tomoki Arichi, Nazakat Merchant, Ioannis S Gousias, A David Edwards, Serena J Counsell

Research output: Contribution to journalArticlepeer-review

231 Citations (Scopus)
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Abstract

Preterm birth is a leading cause of cognitive impairment in childhood and is associated with cerebral gray and white matter abnormalities. Using multimodal image analysis, we tested the hypothesis that altered thalamic development is an important component of preterm brain injury and is associated with other macro- and microstructural alterations. T(1)- and T(2)-weighted magnetic resonance images and 15-direction diffusion tensor images were acquired from 71 preterm infants at term-equivalent age. Deformation-based morphometry, Tract-Based Spatial Statistics, and tissue segmentation were combined for a nonsubjective whole-brain survey of the effect of prematurity on regional tissue volume and microstructure. Increasing prematurity was related to volume reduction in the thalamus, hippocampus, orbitofrontal lobe, posterior cingulate cortex, and centrum semiovale. After controlling for prematurity, reduced thalamic volume predicted: lower cortical volume; decreased volume in frontal and temporal lobes, including hippocampus, and to a lesser extent, parietal and occipital lobes; and reduced fractional anisotropy in the corticospinal tracts and corpus callosum. In the thalamus, reduced volume was associated with increased diffusivity. This demonstrates a significant effect of prematurity on thalamic development that is related to abnormalities in allied brain structures. This suggests that preterm delivery disrupts specific aspects of cerebral development, such as the thalamocortical system.
Original languageEnglish
Pages (from-to)1016-1024
Number of pages9
JournalCerebral cortex (New York, N.Y. : 1991)
Volume22
Issue number5
Early online date19 Jul 2011
DOIs
Publication statusPublished - May 2012

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