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The effect of smoking on COVID-19 severity: a systematic review and meta-analysis

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The effect of smoking on COVID-19 severity : a systematic review and meta-analysis. / Reddy, Rohin K; Charles, Walton N; Sklavounos, Alexandros; Dutt, Atul; Seed, Paul T; Khajuria, Ankur.

In: Journal of Medical Virology, 04.08.2020.

Research output: Contribution to journalArticle

Harvard

Reddy, RK, Charles, WN, Sklavounos, A, Dutt, A, Seed, PT & Khajuria, A 2020, 'The effect of smoking on COVID-19 severity: a systematic review and meta-analysis', Journal of Medical Virology. https://doi.org/10.1002/jmv.26389

APA

Reddy, R. K., Charles, W. N., Sklavounos, A., Dutt, A., Seed, P. T., & Khajuria, A. (2020). The effect of smoking on COVID-19 severity: a systematic review and meta-analysis. Journal of Medical Virology. https://doi.org/10.1002/jmv.26389

Vancouver

Reddy RK, Charles WN, Sklavounos A, Dutt A, Seed PT, Khajuria A. The effect of smoking on COVID-19 severity: a systematic review and meta-analysis. Journal of Medical Virology. 2020 Aug 4. https://doi.org/10.1002/jmv.26389

Author

Reddy, Rohin K ; Charles, Walton N ; Sklavounos, Alexandros ; Dutt, Atul ; Seed, Paul T ; Khajuria, Ankur. / The effect of smoking on COVID-19 severity : a systematic review and meta-analysis. In: Journal of Medical Virology. 2020.

Bibtex Download

@article{2f1efa113f41466a95ba8475c30fd9b5,
title = "The effect of smoking on COVID-19 severity: a systematic review and meta-analysis",
abstract = "Various comorbidities represent risk factors for severe coronavirus disease 2019 (COVID-19). The impact of smoking on COVID-19 severity has been previously reported in several meta-analyses limited by small sample sizes and poor methodology. We aimed to rigorously and definitively quantify the effects of smoking on COVID-19 severity. MEDLINE, Embase, CENTRAL, and Web of Science were searched between 1 December 2019 and 2 June 2020. Studies reporting smoking status of hospitalized patients with different severities of disease and/or at least one clinical endpoint of interest (disease progression, intensive care unit admission, need for mechanical ventilation, and mortality) were included. Data were pooled using a random-effects model. This study was registered on PROSPERO: CRD42020180920. We analyzed 47 eligible studies reporting on 32 849 hospitalized COVID-19 patients, with 8417 (25.6%) reporting a smoking history, comprising 1501 current smokers, 5676 former smokers, and 1240 unspecified smokers. Current smokers had an increased risk of severe COVID-19 (risk ratios [RR]: 1.80; 95% confidence interval [CI]: 1.14-2.85; P =.012), and severe or critical COVID-19 (RR: 1.98; CI: 1.16-3.38; P =.012). Patients with a smoking history had a significantly increased risk of severe COVID-19 (RR: 1.31; CI: 1.12-1.54; P =.001), severe or critical COVID-19 (RR: 1.35; CI: 1.19-1.53; P <.0001), in-hospital mortality (RR: 1.26; CI: 1.20-1.32; P <.0001), disease progression (RR: 2.18; CI: 1.06-4.49; P =.035), and need for mechanical ventilation (RR: 1.20; CI: 1.01-1.42; P =.043). Patients with any smoking history are vulnerable to severe COVID-19 and worse in-hospital outcomes. In the absence of current targeted therapies, preventative, and supportive strategies to reduce morbidity and mortality in current and former smokers are crucial.",
keywords = "Coronavirus < Virus classification, Pandemics < Epidemiology, Zoonoses < Epidemiology, Respiratory tract < Pathogenesis, epidemiology, pathogenesis, respiratory tract, coronavirus, zoonoses, virus classification, pandemics",
author = "Reddy, {Rohin K} and Charles, {Walton N} and Alexandros Sklavounos and Atul Dutt and Seed, {Paul T} and Ankur Khajuria",
note = "This article is protected by copyright. All rights reserved.",
year = "2020",
month = aug,
day = "4",
doi = "10.1002/jmv.26389",
language = "English",
journal = "Journal of Medical Virology",
issn = "1743-422X",
publisher = "Wiley-Liss Inc.",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - The effect of smoking on COVID-19 severity

T2 - a systematic review and meta-analysis

AU - Reddy, Rohin K

AU - Charles, Walton N

AU - Sklavounos, Alexandros

AU - Dutt, Atul

AU - Seed, Paul T

AU - Khajuria, Ankur

N1 - This article is protected by copyright. All rights reserved.

PY - 2020/8/4

Y1 - 2020/8/4

N2 - Various comorbidities represent risk factors for severe coronavirus disease 2019 (COVID-19). The impact of smoking on COVID-19 severity has been previously reported in several meta-analyses limited by small sample sizes and poor methodology. We aimed to rigorously and definitively quantify the effects of smoking on COVID-19 severity. MEDLINE, Embase, CENTRAL, and Web of Science were searched between 1 December 2019 and 2 June 2020. Studies reporting smoking status of hospitalized patients with different severities of disease and/or at least one clinical endpoint of interest (disease progression, intensive care unit admission, need for mechanical ventilation, and mortality) were included. Data were pooled using a random-effects model. This study was registered on PROSPERO: CRD42020180920. We analyzed 47 eligible studies reporting on 32 849 hospitalized COVID-19 patients, with 8417 (25.6%) reporting a smoking history, comprising 1501 current smokers, 5676 former smokers, and 1240 unspecified smokers. Current smokers had an increased risk of severe COVID-19 (risk ratios [RR]: 1.80; 95% confidence interval [CI]: 1.14-2.85; P =.012), and severe or critical COVID-19 (RR: 1.98; CI: 1.16-3.38; P =.012). Patients with a smoking history had a significantly increased risk of severe COVID-19 (RR: 1.31; CI: 1.12-1.54; P =.001), severe or critical COVID-19 (RR: 1.35; CI: 1.19-1.53; P <.0001), in-hospital mortality (RR: 1.26; CI: 1.20-1.32; P <.0001), disease progression (RR: 2.18; CI: 1.06-4.49; P =.035), and need for mechanical ventilation (RR: 1.20; CI: 1.01-1.42; P =.043). Patients with any smoking history are vulnerable to severe COVID-19 and worse in-hospital outcomes. In the absence of current targeted therapies, preventative, and supportive strategies to reduce morbidity and mortality in current and former smokers are crucial.

AB - Various comorbidities represent risk factors for severe coronavirus disease 2019 (COVID-19). The impact of smoking on COVID-19 severity has been previously reported in several meta-analyses limited by small sample sizes and poor methodology. We aimed to rigorously and definitively quantify the effects of smoking on COVID-19 severity. MEDLINE, Embase, CENTRAL, and Web of Science were searched between 1 December 2019 and 2 June 2020. Studies reporting smoking status of hospitalized patients with different severities of disease and/or at least one clinical endpoint of interest (disease progression, intensive care unit admission, need for mechanical ventilation, and mortality) were included. Data were pooled using a random-effects model. This study was registered on PROSPERO: CRD42020180920. We analyzed 47 eligible studies reporting on 32 849 hospitalized COVID-19 patients, with 8417 (25.6%) reporting a smoking history, comprising 1501 current smokers, 5676 former smokers, and 1240 unspecified smokers. Current smokers had an increased risk of severe COVID-19 (risk ratios [RR]: 1.80; 95% confidence interval [CI]: 1.14-2.85; P =.012), and severe or critical COVID-19 (RR: 1.98; CI: 1.16-3.38; P =.012). Patients with a smoking history had a significantly increased risk of severe COVID-19 (RR: 1.31; CI: 1.12-1.54; P =.001), severe or critical COVID-19 (RR: 1.35; CI: 1.19-1.53; P <.0001), in-hospital mortality (RR: 1.26; CI: 1.20-1.32; P <.0001), disease progression (RR: 2.18; CI: 1.06-4.49; P =.035), and need for mechanical ventilation (RR: 1.20; CI: 1.01-1.42; P =.043). Patients with any smoking history are vulnerable to severe COVID-19 and worse in-hospital outcomes. In the absence of current targeted therapies, preventative, and supportive strategies to reduce morbidity and mortality in current and former smokers are crucial.

KW - Coronavirus < Virus classification

KW - Pandemics < Epidemiology

KW - Zoonoses < Epidemiology

KW - Respiratory tract < Pathogenesis

KW - epidemiology

KW - pathogenesis

KW - respiratory tract

KW - coronavirus

KW - zoonoses

KW - virus classification

KW - pandemics

UR - http://www.scopus.com/inward/record.url?scp=85089373873&partnerID=8YFLogxK

U2 - 10.1002/jmv.26389

DO - 10.1002/jmv.26389

M3 - Article

C2 - 32749705

JO - Journal of Medical Virology

JF - Journal of Medical Virology

SN - 1743-422X

ER -

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