@inbook{cad513c625164c73a12a3d92e7dc532a,
title = "The Effect of Ventricular Myofibre Orientation on Atrial Dynamics",
abstract = "Cardiac output is dependent on the tight coupling between atrial and ventricular function. The study of such interaction mechanisms is hindered by their complexity, and therefore requires a systematic approach. We have developed a four-chamber closed-loop cardiac electromechanics model which, through the coupling of the chambers with a closed-loop cardiovascular system model and the effect of the pericardium, is able to capture atrioventricular interaction. Our model simulates electrical activation and contraction of the atria and the ventricles coupled with a closed-loop model based on the CircAdapt framework. We include the effect of the pericardium on the heart using normal springs, scaling the local spring stiffness based on image-derived motion. The coupled model was used to study the impact of ventricular myofibre orientation on atrial dynamics by varying ventricular fibre orientation from –40∘ /+40∘ to –70∘ /+70∘. We found that steeper fibres increase atrioventricular valve plane motion from 1.0 mm to 14.0 mm, leading to a lower minimum left atrial (LA) pressure (–0.4 mmHg vs –1.1 mmHg) and greater venous return (LA maximum volume: 168 mL vs 182 mL), and that fibres angles –50∘ /+50∘ were consistent with a physiological atrial contraction and filling pattern. Our framework is capable of capturing complex interaction dynamics between the atria, the ventricles and the circulatory system accounting for the effect of the pericardium. Such simulation platform represents a useful tool to study both systolic and filling phases of all cardiac chambers, and how these get altered in diseased states and in response to treatment.",
keywords = "Atrioventricular interaction, Electromechanics, Four-chamber model, Pericardium",
author = "Marina Strocchi and Augustin, {Christoph M.} and Gsell, {Matthias A.F.} and Elias Karabelas and Aurel Neic and Karli Gillette and Roney, {Caroline H.} and Orod Razeghi and Behar, {Jonathan M.} and Rinaldi, {Christopher A.} and Vigmond, {Edward J.} and Bishop, {Martin J.} and Gernot Plank and Niederer, {Steven A.}",
note = "Funding Information: Acknowledgement. This study received support from the UK Engineering and Physical Sciences Research Council (EP/M012492/1, NS/A000049/1, EP/L015226/1, and EP/P01268X/1), the Wellcome EPSRC Centre for Medical Engineering (NS/A000049/1 and WT 203148/Z/16/Z), the British Heart Foundation (PG/15/91/31812 and PG/13/37/30280), the National Institute of Health (NIH R01-HL152256), the European Research Council (ERC PREDICT-HF 864055) and King{\textquoteright}s Health Partners London National Institute for Health Research (NIHR) Biomedical Research Centre. Miss Marina Strocchi was supported by an unrestricted Abbott educational grant through the Centre for Doctoral Training in Medical Imaging at King{\textquoteright}s College London. Dr Neic is employed by NumeriCor GmbH, Graz, Austria. All other authors have reported that they have no conflicts relevant to the contents of this paper to disclose. Funding Information: This study received support from the UK Engineering and Physical Sciences Research Council (EP/M012492/1, NS/A000049/1, EP/L015226/1, and EP/P01268X/1), the Wellcome EPSRC Centre for Medical Engineering (NS/A000049/1 and WT 203148/Z/16/Z), the British Heart Foundation (PG/15/91/31812 and PG/13/37/30280), the National Institute of Health (NIH R01-HL152256), the European Research Council (ERC PREDICT-HF 864055) and King?s Health Partners London National Institute for Health Research (NIHR) Biomedical Research Centre. Miss Marina Strocchi was supported by an unrestricted Abbott educational grant through the Centre for Doctoral Training in Medical Imaging at King?s College London. Dr Neic is employed by NumeriCor GmbH, Graz, Austria. All other authors have reported that they have no conflicts relevant to the contents of this paper to disclose. Publisher Copyright: {\textcopyright} 2021, Springer Nature Switzerland AG. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.; 11th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2021 ; Conference date: 21-06-2021 Through 25-06-2021",
year = "2021",
doi = "10.1007/978-3-030-78710-3_63",
language = "English",
isbn = "9783030787097",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "659--670",
editor = "Ennis, {Daniel B.} and Perotti, {Luigi E.} and Wang, {Vicky Y.}",
booktitle = "Functional Imaging and Modeling of the Heart - 11th International Conference, FIMH 2021, Proceedings",
address = "Germany",
}