The Effect of Ventricular Myofibre Orientation on Atrial Dynamics

Marina Strocchi*, Christoph M. Augustin, Matthias A.F. Gsell, Elias Karabelas, Aurel Neic, Karli Gillette, Caroline H. Roney, Orod Razeghi, Jonathan M. Behar, Christopher A. Rinaldi, Edward J. Vigmond, Martin J. Bishop, Gernot Plank, Steven A. Niederer

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

5 Citations (Scopus)


Cardiac output is dependent on the tight coupling between atrial and ventricular function. The study of such interaction mechanisms is hindered by their complexity, and therefore requires a systematic approach. We have developed a four-chamber closed-loop cardiac electromechanics model which, through the coupling of the chambers with a closed-loop cardiovascular system model and the effect of the pericardium, is able to capture atrioventricular interaction. Our model simulates electrical activation and contraction of the atria and the ventricles coupled with a closed-loop model based on the CircAdapt framework. We include the effect of the pericardium on the heart using normal springs, scaling the local spring stiffness based on image-derived motion. The coupled model was used to study the impact of ventricular myofibre orientation on atrial dynamics by varying ventricular fibre orientation from –40 /+40 to –70 /+70. We found that steeper fibres increase atrioventricular valve plane motion from 1.0 mm to 14.0 mm, leading to a lower minimum left atrial (LA) pressure (–0.4 mmHg vs –1.1 mmHg) and greater venous return (LA maximum volume: 168 mL vs 182 mL), and that fibres angles –50 /+50 were consistent with a physiological atrial contraction and filling pattern. Our framework is capable of capturing complex interaction dynamics between the atria, the ventricles and the circulatory system accounting for the effect of the pericardium. Such simulation platform represents a useful tool to study both systolic and filling phases of all cardiac chambers, and how these get altered in diseased states and in response to treatment.

Original languageEnglish
Title of host publicationFunctional Imaging and Modeling of the Heart - 11th International Conference, FIMH 2021, Proceedings
EditorsDaniel B. Ennis, Luigi E. Perotti, Vicky Y. Wang
PublisherSpringer Science and Business Media Deutschland GmbH
Number of pages12
ISBN (Print)9783030787097
Publication statusPublished - 2021
Event11th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2021 - Virtual, Online
Duration: 21 Jun 202125 Jun 2021

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume12738 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Conference11th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2021
CityVirtual, Online


  • Atrioventricular interaction
  • Electromechanics
  • Four-chamber model
  • Pericardium


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