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The effects of Δ9-tetrahydrocannabinol on the dopamine system

Research output: Contribution to journalLiterature reviewpeer-review

Michael A. P. Bloomfield, Abhishekh H. Ashok, Nora D. Volkow, Oliver D. Howes

Original languageUndefined/Unknown
Pages (from-to)369-377
Number of pages9
JournalNATURE
Volume539
Issue number7629
DOIs
Accepted/In press10 Oct 2016
Published16 Nov 2016

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Abstract

The effects of Δ9-tetrahydrocannabinol (THC), the main psychoactive ingredient in cannabis, are a pressing concern for global mental health. Patterns of cannabis use are changing drastically owing to legalization, the availability of synthetic analogues (commonly termed spice), cannavaping and an emphasis on the purported therapeutic effects of cannabis. Many of the reinforcing effects of THC are mediated by the dopamine system. Owing to the complexity of the cannabinoid–dopamine interactions that take place, there is conflicting evidence from human and animal studies concerning the effects of THC on the dopamine system. Acute THC administration causes increased dopamine release and neuron activity, whereas long-term use is associated with blunting of the dopamine system. Future research must examine the long-term and developmental dopaminergic effects of THC.

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