The Effects of Antipsychotics on the Brain: What Have We Learnt from Structural Imaging of Schizophrenia? - A Systematic Review

R. Smieskova; Paolo Fusar-Poli; P. Allen; K. Bendfeldt; R. D. Stieglitz; J. Drewe; E. W. Radue; Philip McGuire; A. Riecher-Roessler; S. J. Borgwardt

doi:10.2174/138161209788957456

The Effects of Antipsychotics on the Brain: What Have We Learnt from Structural Imaging of Schizophrenia? - A Systematic Review

R. Smieskova, Paolo Fusar-Poli, P. Allen, K. Bendfeldt, R. D. Stieglitz, J. Drewe, E. W. Radue, Philip McGuire, A. Riecher-Roessler, S. J. Borgwardt

Research output: Contribution to journal › Literature review › peer-review

183 Citations (Scopus)

Abstract

Despite a large number of neuroimaging studies in schizophrenia reporting subtle brain abnormalities, we do not know to what extent such abnormalities reflect the effects of antipsychotic treatment on brain structure. We therefore systematically reviewed cross-sectional and follow-up structural brain imaging studies of patients with schizophrenia treated with antipsychotics. 30 magnetic resonance imaging (MRI) studies were identified, 24 of them being longitudinal and six cross-sectional structural imaging studies. In patients with schizophrenia treated with antipsychotics, reduced gray matter volume was described, particularly in the frontal and temporal lobes. Structural neuroimaging studies indicate that treatment with typical as well as atypical antipsychotics may affect regional gray matter (GM) volume. In particular, typical antipsychotics led to increased gray matter volume of the basal ganglia, while atypical antipsychotics reversed this effect after switching. Atypical antipsychotics, however, seem to have no effect on basal ganglia structure.

Original language	English
Pages (from-to)	2535 - 2549
Number of pages	15
Journal	Current Pharmaceutical Design
Volume	15
Issue number	22
DOIs	https://doi.org/10.2174/138161209788957456
Publication status	Published - Aug 2009

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Smieskova, R., Fusar-Poli, P., Allen, P., Bendfeldt, K., Stieglitz, R. D., Drewe, J., Radue, E. W., McGuire, P., Riecher-Roessler, A., & Borgwardt, S. J. (2009). The Effects of Antipsychotics on the Brain: What Have We Learnt from Structural Imaging of Schizophrenia? - A Systematic Review. Current Pharmaceutical Design, 15(22), 2535 - 2549. https://doi.org/10.2174/138161209788957456

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title = "The Effects of Antipsychotics on the Brain: What Have We Learnt from Structural Imaging of Schizophrenia? - A Systematic Review",

abstract = "Despite a large number of neuroimaging studies in schizophrenia reporting subtle brain abnormalities, we do not know to what extent such abnormalities reflect the effects of antipsychotic treatment on brain structure. We therefore systematically reviewed cross-sectional and follow-up structural brain imaging studies of patients with schizophrenia treated with antipsychotics. 30 magnetic resonance imaging (MRI) studies were identified, 24 of them being longitudinal and six cross-sectional structural imaging studies. In patients with schizophrenia treated with antipsychotics, reduced gray matter volume was described, particularly in the frontal and temporal lobes. Structural neuroimaging studies indicate that treatment with typical as well as atypical antipsychotics may affect regional gray matter (GM) volume. In particular, typical antipsychotics led to increased gray matter volume of the basal ganglia, while atypical antipsychotics reversed this effect after switching. Atypical antipsychotics, however, seem to have no effect on basal ganglia structure.",

author = "R. Smieskova and Paolo Fusar-Poli and P. Allen and K. Bendfeldt and Stieglitz, {R. D.} and J. Drewe and Radue, {E. W.} and Philip McGuire and A. Riecher-Roessler and Borgwardt, {S. J.}",

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Smieskova, R, Fusar-Poli, P, Allen, P, Bendfeldt, K, Stieglitz, RD, Drewe, J, Radue, EW, McGuire, P, Riecher-Roessler, A & Borgwardt, SJ 2009, 'The Effects of Antipsychotics on the Brain: What Have We Learnt from Structural Imaging of Schizophrenia? - A Systematic Review', Current Pharmaceutical Design, vol. 15, no. 22, pp. 2535 - 2549. https://doi.org/10.2174/138161209788957456

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T2 - What Have We Learnt from Structural Imaging of Schizophrenia? - A Systematic Review

AU - Smieskova, R.

AU - Fusar-Poli, Paolo

AU - Allen, P.

AU - Bendfeldt, K.

AU - Stieglitz, R. D.

AU - Drewe, J.

AU - Radue, E. W.

AU - McGuire, Philip

AU - Riecher-Roessler, A.

AU - Borgwardt, S. J.

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N2 - Despite a large number of neuroimaging studies in schizophrenia reporting subtle brain abnormalities, we do not know to what extent such abnormalities reflect the effects of antipsychotic treatment on brain structure. We therefore systematically reviewed cross-sectional and follow-up structural brain imaging studies of patients with schizophrenia treated with antipsychotics. 30 magnetic resonance imaging (MRI) studies were identified, 24 of them being longitudinal and six cross-sectional structural imaging studies. In patients with schizophrenia treated with antipsychotics, reduced gray matter volume was described, particularly in the frontal and temporal lobes. Structural neuroimaging studies indicate that treatment with typical as well as atypical antipsychotics may affect regional gray matter (GM) volume. In particular, typical antipsychotics led to increased gray matter volume of the basal ganglia, while atypical antipsychotics reversed this effect after switching. Atypical antipsychotics, however, seem to have no effect on basal ganglia structure.

AB - Despite a large number of neuroimaging studies in schizophrenia reporting subtle brain abnormalities, we do not know to what extent such abnormalities reflect the effects of antipsychotic treatment on brain structure. We therefore systematically reviewed cross-sectional and follow-up structural brain imaging studies of patients with schizophrenia treated with antipsychotics. 30 magnetic resonance imaging (MRI) studies were identified, 24 of them being longitudinal and six cross-sectional structural imaging studies. In patients with schizophrenia treated with antipsychotics, reduced gray matter volume was described, particularly in the frontal and temporal lobes. Structural neuroimaging studies indicate that treatment with typical as well as atypical antipsychotics may affect regional gray matter (GM) volume. In particular, typical antipsychotics led to increased gray matter volume of the basal ganglia, while atypical antipsychotics reversed this effect after switching. Atypical antipsychotics, however, seem to have no effect on basal ganglia structure.

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DO - 10.2174/138161209788957456

M3 - Literature review

SN - 1873-4286

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EP - 2549

JO - Current Pharmaceutical Design

JF - Current Pharmaceutical Design

IS - 22

ER -

The Effects of Antipsychotics on the Brain: What Have We Learnt from Structural Imaging of Schizophrenia? - A Systematic Review

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