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The effects of blood pressure reduction on cognitive function: a review of effects based on pooled data from clinical trials

Research output: Contribution to journalLiterature review

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The effects of blood pressure reduction on cognitive function: a review of effects based on pooled data from clinical trials. / Birns, J; Morris, R; Donaldson, N; Kalra, L.

In: Journal of Hypertension, Vol. 24, No. 10, 10.2006, p. 1907 - 1914.

Research output: Contribution to journalLiterature review

Harvard

Birns, J, Morris, R, Donaldson, N & Kalra, L 2006, 'The effects of blood pressure reduction on cognitive function: a review of effects based on pooled data from clinical trials', Journal of Hypertension, vol. 24, no. 10, pp. 1907 - 1914.

APA

Birns, J., Morris, R., Donaldson, N., & Kalra, L. (2006). The effects of blood pressure reduction on cognitive function: a review of effects based on pooled data from clinical trials. Journal of Hypertension, 24(10), 1907 - 1914.

Vancouver

Birns J, Morris R, Donaldson N, Kalra L. The effects of blood pressure reduction on cognitive function: a review of effects based on pooled data from clinical trials. Journal of Hypertension. 2006 Oct;24(10):1907 - 1914.

Author

Birns, J ; Morris, R ; Donaldson, N ; Kalra, L. / The effects of blood pressure reduction on cognitive function: a review of effects based on pooled data from clinical trials. In: Journal of Hypertension. 2006 ; Vol. 24, No. 10. pp. 1907 - 1914.

Bibtex Download

@article{745af7f01e324e0e95918853cf99c6d8,
title = "The effects of blood pressure reduction on cognitive function: a review of effects based on pooled data from clinical trials",
abstract = "Objective To review systematically and synthesize quantitatively the evidence from completed randomized, controlled trials of blood pressure reduction on cognitive performance. Methods MEDLINE, EMBASE and Cochrane databases were searched to identify randomized, controlled trials that measured the effect of blood pressure reduction on cognitive performance. Additional studies were identified by searching bibliographies of retrieved articles and contacting experts in the field. Data were extracted on study quality, blood pressure, performance on cognitive function tests, antihypertensive treatment regimens and the duration of treatment. Studies were reviewed and abstracted independently by two trained researchers. Results Sixteen studies with 19 501 subjects were identified. Modest reductions in blood pressure (<5/3 mmHg) in 13 860 subjects were associated with improvements in Mini Mental State Examination score [ weighted mean difference (WMD) = 0.19; 95% confidence interval (CI) = 0.19 - 0.19] and performance on immediate (WMD = 0.62; 95% CI = 0.21 - 1.02) and delayed (WMD = 0.67; 95% CI = 0.23 - 1.11) logical memory tasks. However, studies in 2380 subjects that included tests of perceptual processing and learning capacity (trail making test-A, paired associated learning test) showed impaired performance (WMD = -1.12 s; 95% CI = -1.22 to -1.02 and WMD = -0.04; 95% CI = -0.04 to -0.04) on these tests. Conclusion Blood pressure lowering may have a heterogeneous effect on different aspects of cognitive function. Future studies with specific cognitive end- points are needed for greater clarity to guide practice",
author = "J Birns and R Morris and N Donaldson and L Kalra",
year = "2006",
month = oct,
language = "English",
volume = "24",
pages = "1907 -- 1914",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - The effects of blood pressure reduction on cognitive function: a review of effects based on pooled data from clinical trials

AU - Birns, J

AU - Morris, R

AU - Donaldson, N

AU - Kalra, L

PY - 2006/10

Y1 - 2006/10

N2 - Objective To review systematically and synthesize quantitatively the evidence from completed randomized, controlled trials of blood pressure reduction on cognitive performance. Methods MEDLINE, EMBASE and Cochrane databases were searched to identify randomized, controlled trials that measured the effect of blood pressure reduction on cognitive performance. Additional studies were identified by searching bibliographies of retrieved articles and contacting experts in the field. Data were extracted on study quality, blood pressure, performance on cognitive function tests, antihypertensive treatment regimens and the duration of treatment. Studies were reviewed and abstracted independently by two trained researchers. Results Sixteen studies with 19 501 subjects were identified. Modest reductions in blood pressure (<5/3 mmHg) in 13 860 subjects were associated with improvements in Mini Mental State Examination score [ weighted mean difference (WMD) = 0.19; 95% confidence interval (CI) = 0.19 - 0.19] and performance on immediate (WMD = 0.62; 95% CI = 0.21 - 1.02) and delayed (WMD = 0.67; 95% CI = 0.23 - 1.11) logical memory tasks. However, studies in 2380 subjects that included tests of perceptual processing and learning capacity (trail making test-A, paired associated learning test) showed impaired performance (WMD = -1.12 s; 95% CI = -1.22 to -1.02 and WMD = -0.04; 95% CI = -0.04 to -0.04) on these tests. Conclusion Blood pressure lowering may have a heterogeneous effect on different aspects of cognitive function. Future studies with specific cognitive end- points are needed for greater clarity to guide practice

AB - Objective To review systematically and synthesize quantitatively the evidence from completed randomized, controlled trials of blood pressure reduction on cognitive performance. Methods MEDLINE, EMBASE and Cochrane databases were searched to identify randomized, controlled trials that measured the effect of blood pressure reduction on cognitive performance. Additional studies were identified by searching bibliographies of retrieved articles and contacting experts in the field. Data were extracted on study quality, blood pressure, performance on cognitive function tests, antihypertensive treatment regimens and the duration of treatment. Studies were reviewed and abstracted independently by two trained researchers. Results Sixteen studies with 19 501 subjects were identified. Modest reductions in blood pressure (<5/3 mmHg) in 13 860 subjects were associated with improvements in Mini Mental State Examination score [ weighted mean difference (WMD) = 0.19; 95% confidence interval (CI) = 0.19 - 0.19] and performance on immediate (WMD = 0.62; 95% CI = 0.21 - 1.02) and delayed (WMD = 0.67; 95% CI = 0.23 - 1.11) logical memory tasks. However, studies in 2380 subjects that included tests of perceptual processing and learning capacity (trail making test-A, paired associated learning test) showed impaired performance (WMD = -1.12 s; 95% CI = -1.22 to -1.02 and WMD = -0.04; 95% CI = -0.04 to -0.04) on these tests. Conclusion Blood pressure lowering may have a heterogeneous effect on different aspects of cognitive function. Future studies with specific cognitive end- points are needed for greater clarity to guide practice

M3 - Literature review

VL - 24

SP - 1907

EP - 1914

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 10

ER -

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