TY - JOUR
T1 - The effects of reality distortion syndrome on salient stimuli processing in patients with schizophrenia: An fMRI study
AU - Michalopoulou, Panagiota
AU - Giampietro, Vincent
AU - Morley, Lucy A.
AU - Azim, Adrian
AU - Kapur, Shitij
AU - Lykouras, Lefteris
AU - Shergill, Sukhwinder S.
PY - 2010/8
Y1 - 2010/8
N2 - Schizophrenia is associated with interpersonal difficulties related to impairments in the processing of facial emotional expressions. The aim of the present study was to identify brain regions associated with reality distortion syndrome reduction in a group of patients with schizophrenia during processing of emotionally salient stimuli. We used functional magnetic resonance imaging to measure cerebral blood oxygenation changes during an implicit emotional task in 11 patients with schizophrenia, who were scanned twice with an interval of 6-8 weeks. We found that reality distortion syndrome reduction was associated with increases in the activation of the affective division of the anterior cingulate and lateral prefrontal cortices. Our findings may indicate that changes in the activation of these regions during processing of emotionally salient stimuli may represent neural markers of patients' symptomatic improvement. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
AB - Schizophrenia is associated with interpersonal difficulties related to impairments in the processing of facial emotional expressions. The aim of the present study was to identify brain regions associated with reality distortion syndrome reduction in a group of patients with schizophrenia during processing of emotionally salient stimuli. We used functional magnetic resonance imaging to measure cerebral blood oxygenation changes during an implicit emotional task in 11 patients with schizophrenia, who were scanned twice with an interval of 6-8 weeks. We found that reality distortion syndrome reduction was associated with increases in the activation of the affective division of the anterior cingulate and lateral prefrontal cortices. Our findings may indicate that changes in the activation of these regions during processing of emotionally salient stimuli may represent neural markers of patients' symptomatic improvement. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
U2 - 10.1016/j.pscychresns.2010.04.010
DO - 10.1016/j.pscychresns.2010.04.010
M3 - Article
VL - 183
SP - 93
EP - 98
JO - Psychiatry Research. Neuroimaging
JF - Psychiatry Research. Neuroimaging
IS - 2
ER -
