The emerging role of the ADAMTS family in vascular diseases

TY - JOUR

T1 - The emerging role of the ADAMTS family in vascular diseases

AU - Rienks, Marieke

AU - Barallobre-Barreiro, Javier

AU - Mayr, Manuel

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family are involved in the degradation of extracellular matrix (ECM) proteins during development, morphogenesis, tissue repair, and remodeling. They differ from other proteases like MMPs (matrix metalloproteinases) with respect to function, binding and anchoring properties, substrate recognition, and half-life. Thus far, the ADAMTS family has attracted less attention in vascular research than MMPs (Figure 1). Recent findings, however, point towards an important role of ADAMTS family members in atherosclerosis, restenosis, and aneurysm formation.

AB - Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family are involved in the degradation of extracellular matrix (ECM) proteins during development, morphogenesis, tissue repair, and remodeling. They differ from other proteases like MMPs (matrix metalloproteinases) with respect to function, binding and anchoring properties, substrate recognition, and half-life. Thus far, the ADAMTS family has attracted less attention in vascular research than MMPs (Figure 1). Recent findings, however, point towards an important role of ADAMTS family members in atherosclerosis, restenosis, and aneurysm formation.

KW - Aggrecan

KW - Aneurysm

KW - Atherosclerosis

KW - Extracellular matrix

KW - Versican

UR - http://www.scopus.com/inward/record.url?scp=85058877432&partnerID=8YFLogxK

U2 - 10.1161/CIRCRESAHA.118.313737

DO - 10.1161/CIRCRESAHA.118.313737

M3 - Review article

C2 - 30566059

AN - SCOPUS:85058877432

SN - 0009-7330

VL - 123

SP - 1279

EP - 1281

JO - Circulation Research

JF - Circulation Research

IS - 12

ER -