The Evaluation of Optic Nerves Using 7 Tesla "Silent" Zero Echo Time Imaging in Patients with Leber's Hereditary Optic Neuropathy with or without Idebenone Treatment

Cezary Grochowski; Mark Symms; Kamil Jonak; Paweł Krukow; Tobias Wood; Emil Ljungberg; Joaquim Enseñat; Katarzyna Nowomiejska; Robert Rejdak; Ryszard Maciejewski; Gareth J Barker

doi:10.3390/jcm9041112

The Evaluation of Optic Nerves Using 7 Tesla "Silent" Zero Echo Time Imaging in Patients with Leber's Hereditary Optic Neuropathy with or without Idebenone Treatment

Cezary Grochowski, Mark Symms, Kamil Jonak, Paweł Krukow, Tobias Wood, Emil Ljungberg, Joaquim Enseñat, Katarzyna Nowomiejska, Robert Rejdak, Ryszard Maciejewski, Gareth J Barker

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Abstract

Magnetic Resonance Imaging (MRI) of the Optic Nerve is difficult due to the fine extended nature of the structure, strong local magnetic field distortions induced by anatomy, and large motion artefacts associated with eye movement. To address these problems we used a Zero Echo Time (ZTE) MRI sequence with an Adiabatic SPectral Inversion Recovery (ASPIR) fat suppression pulse which also imbues the images with Magnetisation Transfer contrast. We investigated an application of the sequence for imaging the optic nerve in subjects with Leber's hereditary optic neuropathy (LHON). Of particular note is the sequence's near-silent operation, which can enhance image quality of the optic nerve by reducing the occurrence of involuntary saccades induced during Magnetic Resonance (MR) scanning.

Original language	English
Journal	Journal of Clinical Medicine
Volume	9
Issue number	4
DOIs	https://doi.org/10.3390/jcm9041112
Publication status	Published - 13 Apr 2020

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10.3390/jcm9041112

jcm-09-01112-v2
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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Grochowski, C., Symms, M., Jonak, K., Krukow, P., Wood, T., Ljungberg, E., Enseñat, J., Nowomiejska, K., Rejdak, R., Maciejewski, R., & Barker, G. J. (2020). The Evaluation of Optic Nerves Using 7 Tesla "Silent" Zero Echo Time Imaging in Patients with Leber's Hereditary Optic Neuropathy with or without Idebenone Treatment. Journal of Clinical Medicine, 9(4). https://doi.org/10.3390/jcm9041112

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title = "The Evaluation of Optic Nerves Using 7 Tesla {"}Silent{"} Zero Echo Time Imaging in Patients with Leber's Hereditary Optic Neuropathy with or without Idebenone Treatment",

abstract = "Magnetic Resonance Imaging (MRI) of the Optic Nerve is difficult due to the fine extended nature of the structure, strong local magnetic field distortions induced by anatomy, and large motion artefacts associated with eye movement. To address these problems we used a Zero Echo Time (ZTE) MRI sequence with an Adiabatic SPectral Inversion Recovery (ASPIR) fat suppression pulse which also imbues the images with Magnetisation Transfer contrast. We investigated an application of the sequence for imaging the optic nerve in subjects with Leber's hereditary optic neuropathy (LHON). Of particular note is the sequence's near-silent operation, which can enhance image quality of the optic nerve by reducing the occurrence of involuntary saccades induced during Magnetic Resonance (MR) scanning.",

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Grochowski, C, Symms, M, Jonak, K, Krukow, P, Wood, T , Ljungberg, E, Enseñat, J, Nowomiejska, K, Rejdak, R, Maciejewski, R & Barker, GJ 2020, 'The Evaluation of Optic Nerves Using 7 Tesla "Silent" Zero Echo Time Imaging in Patients with Leber's Hereditary Optic Neuropathy with or without Idebenone Treatment', Journal of Clinical Medicine, vol. 9, no. 4. https://doi.org/10.3390/jcm9041112

TY - JOUR

T1 - The Evaluation of Optic Nerves Using 7 Tesla "Silent" Zero Echo Time Imaging in Patients with Leber's Hereditary Optic Neuropathy with or without Idebenone Treatment

AU - Grochowski, Cezary

AU - Symms, Mark

AU - Jonak, Kamil

AU - Krukow, Paweł

AU - Wood, Tobias

AU - Ljungberg, Emil

AU - Enseñat, Joaquim

AU - Nowomiejska, Katarzyna

AU - Rejdak, Robert

AU - Maciejewski, Ryszard

AU - Barker, Gareth J

PY - 2020/4/13

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N2 - Magnetic Resonance Imaging (MRI) of the Optic Nerve is difficult due to the fine extended nature of the structure, strong local magnetic field distortions induced by anatomy, and large motion artefacts associated with eye movement. To address these problems we used a Zero Echo Time (ZTE) MRI sequence with an Adiabatic SPectral Inversion Recovery (ASPIR) fat suppression pulse which also imbues the images with Magnetisation Transfer contrast. We investigated an application of the sequence for imaging the optic nerve in subjects with Leber's hereditary optic neuropathy (LHON). Of particular note is the sequence's near-silent operation, which can enhance image quality of the optic nerve by reducing the occurrence of involuntary saccades induced during Magnetic Resonance (MR) scanning.

AB - Magnetic Resonance Imaging (MRI) of the Optic Nerve is difficult due to the fine extended nature of the structure, strong local magnetic field distortions induced by anatomy, and large motion artefacts associated with eye movement. To address these problems we used a Zero Echo Time (ZTE) MRI sequence with an Adiabatic SPectral Inversion Recovery (ASPIR) fat suppression pulse which also imbues the images with Magnetisation Transfer contrast. We investigated an application of the sequence for imaging the optic nerve in subjects with Leber's hereditary optic neuropathy (LHON). Of particular note is the sequence's near-silent operation, which can enhance image quality of the optic nerve by reducing the occurrence of involuntary saccades induced during Magnetic Resonance (MR) scanning.

U2 - 10.3390/jcm9041112

DO - 10.3390/jcm9041112

M3 - Article

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SN - 2077-0383

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JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 4

ER -

The Evaluation of Optic Nerves Using 7 Tesla "Silent" Zero Echo Time Imaging in Patients with Leber's Hereditary Optic Neuropathy with or without Idebenone Treatment

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