The Extended Tau Haplotype and the Age of Onset of Dementia in Down Syndrome

Emma L. Jones; Marisa Margallo-Lana; Vee P. Prasher; Clive G. Ballard

doi:10.1159/000152044

The Extended Tau Haplotype and the Age of Onset of Dementia in Down Syndrome

Emma L. Jones, Marisa Margallo-Lana, Vee P. Prasher, Clive G. Ballard

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22 Citations (Scopus)

Abstract

Background/Aims: Most people with Down syndrome (DS) develop Alzheimer's disease ( AD). The extended tau haplotype has been linked to AD. In this study, we examined the haplotype's effect on the age of onset of AD in DS. Methods: People with DS were assessed for dementia. Genotyping was performed for the extended tau haplotype, APOE and a polymorphism in APP, attt(5-8). Results: Haplotype frequencies vary between those developing AD before 45 and those developing dementia after this age (p = 0.03). H1/H2 individuals are more likely to develop dementia before 45 than H1/H1 individuals (OR = 3, 95% CI = 1.01-8.91). Conclusion: Even in a condition driven by excess amyloid pathology, factors affecting tau are also important and should be considered as potential treatment targets. Copyright (C) 2008 S. Karger AG, Basel

Original language	English
Pages (from-to)	199 - 202
Number of pages	4
Journal	Dementia and Geriatric Cognitive Disorders
Volume	26
Issue number	3
DOIs	https://doi.org/10.1159/000152044
Publication status	Published - Oct 2008

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title = "The Extended Tau Haplotype and the Age of Onset of Dementia in Down Syndrome",

abstract = "Background/Aims: Most people with Down syndrome (DS) develop Alzheimer's disease ( AD). The extended tau haplotype has been linked to AD. In this study, we examined the haplotype's effect on the age of onset of AD in DS. Methods: People with DS were assessed for dementia. Genotyping was performed for the extended tau haplotype, APOE and a polymorphism in APP, attt(5-8). Results: Haplotype frequencies vary between those developing AD before 45 and those developing dementia after this age (p = 0.03). H1/H2 individuals are more likely to develop dementia before 45 than H1/H1 individuals (OR = 3, 95% CI = 1.01-8.91). Conclusion: Even in a condition driven by excess amyloid pathology, factors affecting tau are also important and should be considered as potential treatment targets. Copyright (C) 2008 S. Karger AG, Basel",

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AU - Jones, Emma L.

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AU - Prasher, Vee P.

AU - Ballard, Clive G.

PY - 2008/10

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N2 - Background/Aims: Most people with Down syndrome (DS) develop Alzheimer's disease ( AD). The extended tau haplotype has been linked to AD. In this study, we examined the haplotype's effect on the age of onset of AD in DS. Methods: People with DS were assessed for dementia. Genotyping was performed for the extended tau haplotype, APOE and a polymorphism in APP, attt(5-8). Results: Haplotype frequencies vary between those developing AD before 45 and those developing dementia after this age (p = 0.03). H1/H2 individuals are more likely to develop dementia before 45 than H1/H1 individuals (OR = 3, 95% CI = 1.01-8.91). Conclusion: Even in a condition driven by excess amyloid pathology, factors affecting tau are also important and should be considered as potential treatment targets. Copyright (C) 2008 S. Karger AG, Basel

AB - Background/Aims: Most people with Down syndrome (DS) develop Alzheimer's disease ( AD). The extended tau haplotype has been linked to AD. In this study, we examined the haplotype's effect on the age of onset of AD in DS. Methods: People with DS were assessed for dementia. Genotyping was performed for the extended tau haplotype, APOE and a polymorphism in APP, attt(5-8). Results: Haplotype frequencies vary between those developing AD before 45 and those developing dementia after this age (p = 0.03). H1/H2 individuals are more likely to develop dementia before 45 than H1/H1 individuals (OR = 3, 95% CI = 1.01-8.91). Conclusion: Even in a condition driven by excess amyloid pathology, factors affecting tau are also important and should be considered as potential treatment targets. Copyright (C) 2008 S. Karger AG, Basel

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The Extended Tau Haplotype and the Age of Onset of Dementia in Down Syndrome

Abstract

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