The first five inflations during resuscitation of prematurely born infants

Vadivelam Murthy, Nikesh Dattani, Janet L. Peacock, Grenville Fox, Morag E. Campbell, Anthony D. Milner, Anne Greenough

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Objective: To study the first five inflations during the resuscitation of prematurely born infants and whether the infant's inspiratory efforts influenced the expired tidal volume.

Design: Prospective observational study.

Setting: Two tertiary perinatal centres.

Patients: Thirty infants, median gestational age 30 (23-34) weeks.

Interventions: The first five inflations delivered via a face mask and t-piece device were examined using respiratory function monitoring.

Main outcome measures: Inflation pressures, inflation times and expiratory volumes were recorded and comparison made of inflations during which the infant made an inspiratory effort (active inflation) or did not (passive inflation).

Results: Overall, the median expired tidal volume was 2.5 (0-19.8) ml/kg and was lower for passive (median 2.1 ml/kg, range 0-19.8 ml/kg) compared with active (median 5.6 ml/kg, range 1.2-12.2 ml/kg) inflations (ratio of geometric means 1.85, 95% Cl 1.18 to 28%) (p=0.007). Overall, the median face mask leak was 54.5% and was lower for active (34.5%) compared with passive (60.7%) inflations (mean difference in % leak: 12.4%, 95% Cl 0.9 to 24%) (p=0.0354). There was a significant positive correlation between the expiratory volumes and the inflation pressures (82 between subjects 0.19, p=0.04) and a negative correlation between the expiratory tidal volumes and the face mask leaks (82 between subjects=0.051, p<0.001), but there was no significant correlation between the inflation times and the expiratory tidal volumes.

Conclusion: The expired tidal volume, inflation pressures and times during the first five inflations during resuscitation were variable. The expired tidal volumes were significantly greater if the infant inspired during the inflation.

Original languageEnglish
Pages (from-to)F249-F253
Number of pages5
JournalArchives of Disease in Childhood Fetal and Neonatal Edition
Issue number4
Early online date15 Dec 2011
Publication statusPublished - Jul 2012


  • Inhalation
  • Perinatal Care
  • Humans
  • Gestational Age
  • Infant, Newborn
  • Monitoring, Physiologic
  • Infant, Premature
  • Resuscitation
  • Tidal Volume
  • Masks
  • Prospective Studies
  • Positive-Pressure Respiration
  • Female
  • Male


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