The forces and fates of extruding cells

John Fadul, Jody Rosenblatt

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)

Abstract

Cell extrusion drives most epithelial cell death while maintaining a functional epithelial barrier. To extrude, a cell produces a lipid signal that triggers the neighboring cells to reorganize actin and myosin basally to squeeze the extruding cell out apically from the barrier. More studies continue to reveal other signals and mechanisms controlling apical extrusion. New developmental studies are uncovering mechanisms controlling basal extrusion, or ingression, which occurs when apical extrusion is defective or during de-differentiation in development. Here, we review recent advances in epithelial extrusion, focusing particularly on forces exerted upon extruding cells and their various later fates ranging from cell death, normal development, and cancer.

Original languageEnglish
Pages (from-to)66-71
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume54
Early online date1 May 2018
DOIs
Publication statusPublished - Oct 2018

Keywords

  • Actins/metabolism
  • Animals
  • Biomechanical Phenomena
  • Disease
  • Epithelial Cells/cytology
  • Humans
  • Myosins/metabolism
  • Nervous System/growth & development

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